Statistical Analysis and Reporting of Cardiac Output Method Comparison Studies (COMPARE) Statement

Bernd Saugel; Alexander Hapfelmeier; Moritz Flick; Joseph Rinehart; Robert H. Thiele; Simon T. Vistisen; Karsten Bartels; Maxime Cannesson; Maurizio Cecconi; Michelle S. Chew; Daniel De Backer; Alexandre Joosten; Ashish K. Khanna; Jerrold H. Levy; Agnes S. Meidert; Antonio Messina; Xavier Monnet; Sheila N. Myatra; Michael R. Pinsky; Alparslan Turan; Iwan C.C. Van Der Horst; Jean Louis Vincent; Karim Kouz

doi:10.1097/ALN.0000000000005559

Statistical Analysis and Reporting of Cardiac Output Method Comparison Studies (COMPARE) Statement

Bernd Saugel
, Alexander Hapfelmeier
, Moritz Flick
, Joseph Rinehart
, Robert H. Thiele
, Simon T. Vistisen
, Karsten Bartels
, Maxime Cannesson
, Maurizio Cecconi
, Michelle S. Chew
, Daniel De Backer
, Alexandre Joosten
, Ashish K. Khanna
, Jerrold H. Levy
, Agnes S. Meidert
, Antonio Messina
, Xavier Monnet
, Sheila N. Myatra
, Michael R. Pinsky
, Alparslan Turan

Iwan C.C. Van Der Horst, Jean Louis Vincent, Karim Kouz

Institute of General Medicine

Universitätsklinikum Hamburg-Eppendorf
Outcomes Research Consortium
University of California-Irvine
University of Virginia
Aarhus University
University of Michigan Medical School
David Geffen School of Medicine at UCLA
Humanitas University
Humanitas Clinical and Research Center
Karolinska Institutet
Université Libre de Bruxelles
Wake Forest School of Medicine
Duke University
Ludwig-Maximilians-Universität München
Inserm UMR-S999
Tata Memorial Hospital
University of Pittsburgh
McGovern Medical School
Maastricht University Medical Center
Maastricht University
Free University of Brussels

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Cardiac output is a key cardiovascular variable quantifying global blood flow. The measurement performance of cardiac output monitoring methods is investigated in validation studies, which are method comparison studies determining the agreement between cardiac output values measured with a test method and those measured with a reference method. The StatistiCal analysis and repOrting of cardiac output Method comPARison studiEs (COMPARE) statement provides a framework for designing, performing, and reporting cardiac output method comparison studies and includes a checklist of 29 items that are essential for reporting of those studies. Considering and reporting the items specified in the COMPARE checklist will help standardize cardiac output method comparison studies and increase the external validity of the results.

Original language	English
Pages (from-to)	518-532
Number of pages	15
Journal	Anesthesiology
Volume	143
Issue number	3
DOIs	https://doi.org/10.1097/ALN.0000000000005559
State	Published - 1 Sep 2025

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Saugel, B., Hapfelmeier, A., Flick, M., Rinehart, J., Thiele, R. H., Vistisen, S. T., Bartels, K., Cannesson, M., Cecconi, M., Chew, M. S., De Backer, D., Joosten, A., Khanna, A. K., Levy, J. H., Meidert, A. S., Messina, A., Monnet, X., Myatra, S. N., Pinsky, M. R., ... Kouz, K. (2025). Statistical Analysis and Reporting of Cardiac Output Method Comparison Studies (COMPARE) Statement. Anesthesiology, 143(3), 518-532. https://doi.org/10.1097/ALN.0000000000005559

@article{9c1701fb511842c1a5d2ff37602753ac,

title = "Statistical Analysis and Reporting of Cardiac Output Method Comparison Studies (COMPARE) Statement",

abstract = "Cardiac output is a key cardiovascular variable quantifying global blood flow. The measurement performance of cardiac output monitoring methods is investigated in validation studies, which are method comparison studies determining the agreement between cardiac output values measured with a test method and those measured with a reference method. The StatistiCal analysis and repOrting of cardiac output Method comPARison studiEs (COMPARE) statement provides a framework for designing, performing, and reporting cardiac output method comparison studies and includes a checklist of 29 items that are essential for reporting of those studies. Considering and reporting the items specified in the COMPARE checklist will help standardize cardiac output method comparison studies and increase the external validity of the results.",

author = "Bernd Saugel and Alexander Hapfelmeier and Moritz Flick and Joseph Rinehart and Thiele, \{Robert H.\} and Vistisen, \{Simon T.\} and Karsten Bartels and Maxime Cannesson and Maurizio Cecconi and Chew, \{Michelle S.\} and \{De Backer\}, Daniel and Alexandre Joosten and Khanna, \{Ashish K.\} and Levy, \{Jerrold H.\} and Meidert, \{Agnes S.\} and Antonio Messina and Xavier Monnet and Myatra, \{Sheila N.\} and Pinsky, \{Michael R.\} and Alparslan Turan and \{Van Der Horst\}, \{Iwan C.C.\} and Vincent, \{Jean Louis\} and Karim Kouz",

year = "2025",

month = sep,

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doi = "10.1097/ALN.0000000000005559",

language = "English",

volume = "143",

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Saugel, B, Hapfelmeier, A, Flick, M, Rinehart, J, Thiele, RH, Vistisen, ST, Bartels, K, Cannesson, M, Cecconi, M, Chew, MS, De Backer, D, Joosten, A, Khanna, AK, Levy, JH, Meidert, AS, Messina, A, Monnet, X, Myatra, SN, Pinsky, MR, Turan, A, Van Der Horst, ICC, Vincent, JL & Kouz, K 2025, 'Statistical Analysis and Reporting of Cardiac Output Method Comparison Studies (COMPARE) Statement', Anesthesiology, vol. 143, no. 3, pp. 518-532. https://doi.org/10.1097/ALN.0000000000005559

TY - JOUR

T1 - Statistical Analysis and Reporting of Cardiac Output Method Comparison Studies (COMPARE) Statement

AU - Saugel, Bernd

AU - Hapfelmeier, Alexander

AU - Flick, Moritz

AU - Rinehart, Joseph

AU - Thiele, Robert H.

AU - Vistisen, Simon T.

AU - Bartels, Karsten

AU - Cannesson, Maxime

AU - Cecconi, Maurizio

AU - Chew, Michelle S.

AU - De Backer, Daniel

AU - Joosten, Alexandre

AU - Khanna, Ashish K.

AU - Levy, Jerrold H.

AU - Meidert, Agnes S.

AU - Messina, Antonio

AU - Monnet, Xavier

AU - Myatra, Sheila N.

AU - Pinsky, Michael R.

AU - Turan, Alparslan

AU - Van Der Horst, Iwan C.C.

AU - Vincent, Jean Louis

AU - Kouz, Karim

PY - 2025/9/1

Y1 - 2025/9/1

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Statistical Analysis and Reporting of Cardiac Output Method Comparison Studies (COMPARE) Statement

Abstract

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