Stat5a sobers up inTOXicated T cells

Lara V. Donhauser; Dietmar Zehn

doi:10.1016/j.immuni.2023.11.013

Stat5a sobers up inTOXicated T cells

Lara V. Donhauser, Dietmar Zehn

Chair of Animal Physiology and Immunology

Technical University of Munich

Research output: Contribution to journal › Comment/debate

Abstract

Exhausted T cells are largely hampered by epigenetically enforced mechanisms that limit their effector potential. In this issue of Immunity, Beltra et al. found that Stat5 can alter these epigenetic profiles when T cells transition from the Tpex precursor stage into differentiated cells. At this stage, enforced Stat5 expression increases the number of intermediate exhausted T cells and induces durable effector cells with superior anti-tumor activity.

Original language	English
Pages (from-to)	2670-2672
Number of pages	3
Journal	Immunity
Volume	56
Issue number	12
DOIs	https://doi.org/10.1016/j.immuni.2023.11.013
State	Published - 12 Dec 2023

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10.1016/j.immuni.2023.11.013

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title = "Stat5a sobers up inTOXicated T cells",

abstract = "Exhausted T cells are largely hampered by epigenetically enforced mechanisms that limit their effector potential. In this issue of Immunity, Beltra et al. found that Stat5 can alter these epigenetic profiles when T cells transition from the Tpex precursor stage into differentiated cells. At this stage, enforced Stat5 expression increases the number of intermediate exhausted T cells and induces durable effector cells with superior anti-tumor activity.",

author = "Donhauser, {Lara V.} and Dietmar Zehn",

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year = "2023",

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AU - Donhauser, Lara V.

AU - Zehn, Dietmar

PY - 2023/12/12

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N2 - Exhausted T cells are largely hampered by epigenetically enforced mechanisms that limit their effector potential. In this issue of Immunity, Beltra et al. found that Stat5 can alter these epigenetic profiles when T cells transition from the Tpex precursor stage into differentiated cells. At this stage, enforced Stat5 expression increases the number of intermediate exhausted T cells and induces durable effector cells with superior anti-tumor activity.

AB - Exhausted T cells are largely hampered by epigenetically enforced mechanisms that limit their effector potential. In this issue of Immunity, Beltra et al. found that Stat5 can alter these epigenetic profiles when T cells transition from the Tpex precursor stage into differentiated cells. At this stage, enforced Stat5 expression increases the number of intermediate exhausted T cells and induces durable effector cells with superior anti-tumor activity.

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U2 - 10.1016/j.immuni.2023.11.013

DO - 10.1016/j.immuni.2023.11.013

M3 - Comment/debate

AN - SCOPUS:85179474786

SN - 1074-7613

VL - 56

SP - 2670

EP - 2672

JO - Immunity

JF - Immunity

IS - 12

ER -

Stat5a sobers up inTOXicated T cells

Abstract

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