Abstract
Peripheral blood mononuclear cells from patients with atopic eczema (AE) stimulated with the 'superantigen' Staphylococcus enterotoxin B (SEB) secreted significantly more interleukin (IL)-4 and IL-5 as well as IgE, and markedly less interferon-γ than those from healthy controls. Our results support the assumption that SEB produced by S. aureus colonizing the skin of patients with AE may induce expansion of IL-4- and IL-5-producing Th2 clones, leading to increased IgE synthesis and eosinophil activation.
| Original language | English |
|---|---|
| Pages (from-to) | 179-182 |
| Number of pages | 4 |
| Journal | International Archives of Allergy and Immunology |
| Volume | 107 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - 1995 |
| Externally published | Yes |
Keywords
- Atopic eczema
- Cytokines
- IgE
- Staphylococcal enterotoxin B
- Staphylococcus aureus