STAND UND ENTWICKLUNG NEUER KLINISCHER KONTRASTMITTEL FUR DIE MR-DIAGNOSTIK VON LEBERERKRANKUNGEN

Translated title of the contribution: Advances in the development of contrast media for the diagnosis of liver disease by MRI

E. J. Rummeny, P. E. Peters

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

MR contrast agents are developed for pharmaceutical manipulation of tissue signal intensities. Today it is widely recognized that MR contrast agents will play an increasingly important role in MR imaging of the liver. Contrast-enhanced MR-imaging allows to obtain simultaneously dynamic physiologic information and high anatomic detail. Up to now three major classes of MR contrast agents are available for clinical MR-imaging of the liver. These include paramagnetic perfusion agents, hepatobiliary agents,and superparamagnetic RES-specific iron oxide particles. A fourth class of contrast agents now in use for animal experiments includes ultrasmall superparamagnetic particles which can be targeted to extrareticuloendothelial structures such as asialoglycoprotein receptors of hepatocytes. In this article, we review recent advances in the development of MR contrast media and the clinical status of contrast-enhanced MR imaging of the liver.

Translated title of the contributionAdvances in the development of contrast media for the diagnosis of liver disease by MRI
Original languageGerman
Pages (from-to)225-231
Number of pages7
JournalRadiologe
Volume32
Issue number5
StatePublished - 1992
Externally publishedYes

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