Stable and reusable Ni-based nanoparticles for general and selective hydrogenation of nitriles to amines

Zhuang Ma, Vishwas G. Chandrashekhar, Bei Zhou, Asma M. Alenad, Nils Rockstroh, Stephan Bartling, Matthias Beller, Rajenahally V. Jagadeesh

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Silica supported ultrasmall Ni-nanoparticles allow for general and selective hydrogenation of all kinds of nitriles to primary amines under mild conditions. By calcination of a template material generated from Ni(ii)nitrate and colloidal silica under air and subsequent reduction in the presence of molecular hydrogen the optimal catalyst is prepared. The prepared supported nanoparticles are stable, can be conveniently used and easily recycled. The applicability of the optimal catalyst material is shown by hydrogenation of >110 diverse aliphatic and aromatic nitriles including functionalized and industrially relevant substrates. Challenging heterocyclic nitriles, specifically cyanopyridines, provided the corresponding primary amines in good to excellent yields. The resulting amines serve as important precursors and intermediates for the preparation of numerous life science products and polymers.

Original languageEnglish
Pages (from-to)10914-10922
Number of pages9
JournalChemical Science
Volume13
Issue number36
DOIs
StatePublished - 2 Sep 2022
Externally publishedYes

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