TY - JOUR
T1 - Spun biotextiles in tissue engineering and biomolecules delivery systems
AU - Miranda, Catarina S.
AU - Ribeiro, Ana R.M.
AU - Homem, Natália C.
AU - Felgueiras, Helena P.
N1 - Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/4
Y1 - 2020/4
N2 - Nowadays, tissue engineering is described as an interdisciplinary field that combines engineering principles and life sciences to generate implantable devices to repair, restore and/or improve functions of injured tissues. Such devices are designed to induce the interaction and integration of tissue and cells within the implantable matrices and are manufactured to meet the appropriate physical, mechanical and physiological local demands. Biodegradable constructs based on polymeric fibers are desirable for tissue engineering due to their large surface area, interconnectivity, open pore structure, and controlled mechanical strength. Additionally, biodegradable constructs are also very sought-out for biomolecule delivery systems with a targetdirected action. In the present review, we explore the properties of some of the most common biodegradable polymers used in tissue engineering applications and biomolecule delivery systems and highlight their most important uses.
AB - Nowadays, tissue engineering is described as an interdisciplinary field that combines engineering principles and life sciences to generate implantable devices to repair, restore and/or improve functions of injured tissues. Such devices are designed to induce the interaction and integration of tissue and cells within the implantable matrices and are manufactured to meet the appropriate physical, mechanical and physiological local demands. Biodegradable constructs based on polymeric fibers are desirable for tissue engineering due to their large surface area, interconnectivity, open pore structure, and controlled mechanical strength. Additionally, biodegradable constructs are also very sought-out for biomolecule delivery systems with a targetdirected action. In the present review, we explore the properties of some of the most common biodegradable polymers used in tissue engineering applications and biomolecule delivery systems and highlight their most important uses.
KW - Local and systemic biomolecule delivery
KW - Micro-and nanofibers
KW - Regenerative medicine
KW - Soft and hard tissue substitution
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85083365944&partnerID=8YFLogxK
U2 - 10.3390/antibiotics9040174
DO - 10.3390/antibiotics9040174
M3 - Review article
AN - SCOPUS:85083365944
SN - 2079-6382
VL - 9
JO - Antibiotics
JF - Antibiotics
IS - 4
M1 - 174
ER -
