Sport und Ernährung in der Prävention des erblichen Brustkrebses

The modern western lifestyle is characterized by increasing rates of obesity, a lack of physical activity, and unhealthy nutrition. Together with alcohol consumption and nicotine abuse, these factors are considered to be key factors in the development of a variety of cancer diseases, particularly breast cancer. Moreover, evidence suggests that even in women with an inherited predisposition to breast cancer as the result of a mutation in the germline genes BRCA1 and BRCA2, physical activity and a normal body weight might result in a reduction of cancer risk. The LIBRE study is the first prospective randomized lifestyle intervention study for carriers of a pathogenic BRCA1/2 germline mutation, aiming to investigate the long-term impact of behavior modification on breast cancer incidence, prognosis, and mortality. Targeted prevention and additional treatment choices for hereditary and sporadic breast cancer are the main future objectives described in this work.