Spontaneous epileptiform activity of ca1 hippocampal neurons in low extracellular calcium solutions

Y. Yaari, A. Konnerth, U. Heinemann

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123 Scopus citations

Abstract

Lowering extracellular [Ca2+] in rat hippocampal slices induces spontaneous epileptiform activity in area CA1, which is characterized by rhythmic burst firing of CA1 neurons and by prolonged negative potential shifts at the pyramidal cell body layer. This activity is accompanied by transient decreases of [Na+] and increases of [K+] in the extracellular space. In spite of the complete blockade of synaptic transmission, the wave of epileptiform activity propagates across area CA1. These findings suggest, that non-synaptic mechanisms may play a role in the generation and spread of epileptiform activity in the mammalian CNS.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalExperimental Brain Research
Volume51
Issue number1
DOIs
StatePublished - Jun 1983
Externally publishedYes

Keywords

  • CA1 pyramidal cells
  • EGTA
  • Epileptiform activity
  • Hippocampal slice
  • Low calcium
  • Rats

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