Spatiotemporal distribution of white matter lesions in relapsing-remitting and secondary progressive multiple sclerosis

Lukas Filli, Louis Hofstetter, Pascal Kuster, Stefan Traud, Nicole Mueller-Lenke, Yvonne Naegelin, Ludwig Kappos, Achim Gass, Till Sprenger, Thomas E. Nichols, Hugo Vrenken, Frederik Barkhof, Chris Polman, Ernst Wilhelm Radue, Stefan J. Borgwardt, Kerstin Bendfeldt

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. MS lesions show a typical distribution pattern and primarily affect the white matter (WM) in the periventricular zone and in the centrum semiovale. Objective: To track lesion development during disease progression, we compared the spatiotemporal distribution patterns of lesions in relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS). Methods: We used T1 and T2 weighted MR images of 209 RRMS and 62 SPMS patients acquired on two different 1.5 Tesla MR scanners in two clinical centers followed up for 25 (± 1.7) months. Both cross-sectional and longitudinal differences in lesion distribution between RRMS and SPMS patients were analyzed with lesion probability maps (LPMs) and permutation-based inference. Results: MS lesions clustered around the lateral ventricles and in the centrum semiovale. Cross-sectionally, compared to RRMS patients, the SPMS patients showed a significantly higher regional probability of T1 hypointense lesions (p=0.03) in the callosal body, the corticospinal tract, and other tracts adjacent to the lateral ventricles, but not of T2 lesions (peak probabilities were RRMS: T1 9%, T2 18%; SPMS: T1 21%, T2 27%). No longitudinal changes of regional T1 and T2 lesion volumes between baseline and follow-up scan were found. Conclusion: The results suggest a particular vulnerability to neurodegeneration during disease progression in a number of WM tracts.

Original languageEnglish
Pages (from-to)1577-1584
Number of pages8
JournalMultiple Sclerosis Journal
Volume18
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

Keywords

  • MRI
  • Multiple sclerosis
  • T1 hypointense lesions
  • T2 hyperintense lesions
  • lesion probability maps
  • relapsing-remitting
  • secondary progressive
  • white matter

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