Spatial and Spectral Mapping and Decomposition of Neural Dynamics and Organization of the Mouse Brain with Multispectral Optoacoustic Tomography

Ivan Olefir; Ara Ghazaryan; Hong Yang; Jaber Malekzadeh-Najafabadi; Sarah Glasl; Panagiotis Symvoulidis; Valerie B. O'Leary; George Sergiadis; Vasilis Ntziachristos; Saak V. Ovsepian

doi:10.1016/j.celrep.2019.02.020

Spatial and Spectral Mapping and Decomposition of Neural Dynamics and Organization of the Mouse Brain with Multispectral Optoacoustic Tomography

Ivan Olefir, Ara Ghazaryan, Hong Yang, Jaber Malekzadeh-Najafabadi, Sarah Glasl, Panagiotis Symvoulidis, Valerie B. O'Leary, George Sergiadis, Vasilis Ntziachristos, Saak V. Ovsepian

Chair of Biological Imaging

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Olefir et al. apply multispectral optoacoustic (photoacoustic) tomography (MSOT) for noninvasive spatial and spectral mapping and decomposition of neural dynamics and organization of the intact mouse brain in vivo. The results extend the boundaries of noninvasive high-resolution observations beyond the reach of intravital optical neuroimaging in small-animal studies.

Original language	English
Pages (from-to)	2833-2846.e3
Journal	Cell Reports
Volume	26
Issue number	10
DOIs	https://doi.org/10.1016/j.celrep.2019.02.020
State	Published - 5 Mar 2019

Keywords

hemodynamic response
label-free interrogation
near-infrared neuroimaging
photoacoustic imaging
temporal coherence
whole-brain tomography

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10.1016/j.celrep.2019.02.020

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Olefir, I., Ghazaryan, A., Yang, H., Malekzadeh-Najafabadi, J., Glasl, S., Symvoulidis, P., O'Leary, V. B., Sergiadis, G., Ntziachristos, V., & Ovsepian, S. V. (2019). Spatial and Spectral Mapping and Decomposition of Neural Dynamics and Organization of the Mouse Brain with Multispectral Optoacoustic Tomography. Cell Reports, 26(10), 2833-2846.e3. https://doi.org/10.1016/j.celrep.2019.02.020

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title = "Spatial and Spectral Mapping and Decomposition of Neural Dynamics and Organization of the Mouse Brain with Multispectral Optoacoustic Tomography",

abstract = "Olefir et al. apply multispectral optoacoustic (photoacoustic) tomography (MSOT) for noninvasive spatial and spectral mapping and decomposition of neural dynamics and organization of the intact mouse brain in vivo. The results extend the boundaries of noninvasive high-resolution observations beyond the reach of intravital optical neuroimaging in small-animal studies.",

keywords = "hemodynamic response, label-free interrogation, near-infrared neuroimaging, photoacoustic imaging, temporal coherence, whole-brain tomography",

author = "Ivan Olefir and Ara Ghazaryan and Hong Yang and Jaber Malekzadeh-Najafabadi and Sarah Glasl and Panagiotis Symvoulidis and O'Leary, {Valerie B.} and George Sergiadis and Vasilis Ntziachristos and Ovsepian, {Saak V.}",

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Olefir, I, Ghazaryan, A, Yang, H, Malekzadeh-Najafabadi, J, Glasl, S, Symvoulidis, P, O'Leary, VB, Sergiadis, G, Ntziachristos, V & Ovsepian, SV 2019, 'Spatial and Spectral Mapping and Decomposition of Neural Dynamics and Organization of the Mouse Brain with Multispectral Optoacoustic Tomography', Cell Reports, vol. 26, no. 10, pp. 2833-2846.e3. https://doi.org/10.1016/j.celrep.2019.02.020

TY - JOUR

T1 - Spatial and Spectral Mapping and Decomposition of Neural Dynamics and Organization of the Mouse Brain with Multispectral Optoacoustic Tomography

AU - Olefir, Ivan

AU - Ghazaryan, Ara

AU - Yang, Hong

AU - Malekzadeh-Najafabadi, Jaber

AU - Glasl, Sarah

AU - Symvoulidis, Panagiotis

AU - O'Leary, Valerie B.

AU - Sergiadis, George

AU - Ntziachristos, Vasilis

AU - Ovsepian, Saak V.

PY - 2019/3/5

Y1 - 2019/3/5

N2 - Olefir et al. apply multispectral optoacoustic (photoacoustic) tomography (MSOT) for noninvasive spatial and spectral mapping and decomposition of neural dynamics and organization of the intact mouse brain in vivo. The results extend the boundaries of noninvasive high-resolution observations beyond the reach of intravital optical neuroimaging in small-animal studies.

AB - Olefir et al. apply multispectral optoacoustic (photoacoustic) tomography (MSOT) for noninvasive spatial and spectral mapping and decomposition of neural dynamics and organization of the intact mouse brain in vivo. The results extend the boundaries of noninvasive high-resolution observations beyond the reach of intravital optical neuroimaging in small-animal studies.

KW - hemodynamic response

KW - label-free interrogation

KW - near-infrared neuroimaging

KW - photoacoustic imaging

KW - temporal coherence

KW - whole-brain tomography

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DO - 10.1016/j.celrep.2019.02.020

M3 - Article

C2 - 30840901

AN - SCOPUS:85062088671

SN - 2211-1247

VL - 26

SP - 2833-2846.e3

JO - Cell Reports

JF - Cell Reports

IS - 10

ER -

Spatial and Spectral Mapping and Decomposition of Neural Dynamics and Organization of the Mouse Brain with Multispectral Optoacoustic Tomography

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Keywords

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