Abstract
The aim of this investigation was to minimize the experimental effort for solvent system selection in counter-current chromatography. The separation mechanism in counter-current chromatography is based exclusively on the partitioning of the solute between the two liquid phases. Therefore, a quantum chemical method combined with statistical thermodynamics (conductor-like screening model for real solvents, COSMO-RS) was used for the prediction of the partition coefficient. A comparison of the experimental and predicted data for five model solutes systems demonstrated the potential of the use of COSMO-RS as a screening tool for the solvent system selection.
| Original language | English |
|---|---|
| Pages (from-to) | 242-250 |
| Number of pages | 9 |
| Journal | Journal of Chromatography A |
| Volume | 1218 |
| Issue number | 2 |
| DOIs | |
| State | Published - 14 Jan 2011 |
| Externally published | Yes |
Keywords
- COSMO-RS
- Counter-current chromatography
- Solvent system screening
- Solvent system selection
- Two-phase liquid system
Fingerprint
Dive into the research topics of 'Solvent system selection in counter-current chromatography using conductor-like screening model for real solvents'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver