Solid-phase synthesis of 1,3-azole-based peptides and peptidomimetics

Eric Biron, Jayanta Chatterjee, Horst Kessler

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

We report highly efficient two-step procedures for the synthesis of 1,3-oxazole-, thiazole-, and imidazole-containing peptides on solid phase from dipeptides composed of C-terminal threonine, serine, cysteine, or diaminopropionic acid by using different cyclodehydration procedures followed or preceded by oxidation. The methods are compatible with Fmoc solid-phase peptide synthesis conditions and with N-Fmoc, N-Boc, N-Cbz, and N-Alloc protecting groups.

Original languageEnglish
Pages (from-to)2417-2420
Number of pages4
JournalOrganic Letters
Volume8
Issue number11
DOIs
StatePublished - 25 May 2006

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