@article{5c2bdba72fe84f3abd7ca83952c71786,
title = "Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients",
abstract = "Introduction: Microstructural alterations as assessed by diffusion tensor imaging (DTI) are key findings in both Alzheimer's disease (AD) and small vessel disease (SVD). We determined the contribution of each of these conditions to diffusion alterations. Methods: We studied six samples (N = 365 participants) covering the spectrum of AD and SVD, including genetically defined samples. We calculated diffusion measures from DTI and free water imaging. Simple linear, multivariable random forest, and voxel-based regressions were used to evaluate associations between AD biomarkers (amyloid beta, tau), SVD imaging markers, and diffusion measures. Results: SVD markers were strongly associated with diffusion measures and showed a higher contribution than AD biomarkers in multivariable analysis across all memory clinic samples. Voxel-wise analyses between tau and diffusion measures were not significant. Discussion: In memory clinic patients, the effect of SVD on diffusion alterations largely exceeds the effect of AD, supporting the value of diffusion measures as markers of SVD.",
keywords = "Alzheimer's disease, biomarker, cerebral small vessel disease, diffusion tensor imaging, free water imaging, white matter",
author = "{Dominantly Inherited Alzheimer Network (DIAN)} and {DELCODE study group} and {Alzheimer's Disease Neuroimaging Initiative (ADNI)} and {Utrecht VCI study group} and Sofia Finsterwalder and Naomi Vlegels and Benno Gesierich and {Araque Caballero}, Miguel and Weaver, {Nick A.} and Nicolai Franzmeier and Georgakis, {Marios K.} and Konieczny, {Marek J.} and Koek, {Huiberdina L.} and Karch, {Celeste M.} and Graff-Radford, {Neill R.} and Stephen Salloway and Hwamee Oh and Allegri, {Ricardo F.} and Chhatwal, {Jasmeer P.} and Frank Jessen and Emrah D{\"u}zel and Laura Dobisch and Coraline Metzger and Oliver Peters and Incesoy, {Enise I.} and Josef Priller and Spruth, {Eike J.} and Anja Schneider and Klaus Flie{\ss}bach and Katharina Buerger and Daniel Janowitz and Teipel, {Stefan J.} and Ingo Kilimann and Christoph Laske and Martina Buchmann and Heneka, {Michael T.} and Frederic Brosseron and Annika Spottke and Nina Roy and Birgit Ertl-Wagner and Klaus Scheffler and Seo, {Sang Won} and Yeshin Kim and Na, {Duk L.} and Kim, {Hee Jin} and Hyemin Jang and Michael Ewers and Johannes Levin and Reinhold Schmidt and Ofer Pasternak and Martin Dichgans and Biessels, {Geert Jan} and Marco Duering",
note = "Publisher Copyright: {\textcopyright} 2020 the Alzheimer's Association",
year = "2020",
month = nov,
doi = "10.1002/alz.12150",
language = "English",
volume = "16",
pages = "1504--1514",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "John Wiley and Sons Inc.",
number = "11",
}
