TY - CHAP
T1 - Small Animal Models of Tissue Regeneration
AU - Fierro, Fernando A.
AU - Egana, J. Tomas
AU - Toupadakis, Chrisoula A.
AU - Yellowley, Claire
AU - Machens, Hans Günther
AU - Nolta, Jan A.
N1 - Publisher Copyright:
© Springer Science+Business Media, LLC 2011.
PY - 2011
Y1 - 2011
N2 - In order to develop new therapies for tissue regeneration, experimentation in nonhuman animals is fundamental. To a great extent, animal models serve as the link between in vitro stem cell manipulation and synthesis of products, such as synthetic matrices and organs, and clinical application. Animal models are indeed the basic tool to evaluate biosafety and efficacy of new technologies prior to their application in human patients and these models contribute greatly to our understanding of the underlying mechanisms involved in the regenerative process. In this chapter, we outline important rodent models used in the field of tissue repair, highlighting key immune-deficient mouse strains for transplantation of human stem cells. We also present examples of methods to be used in mice to mimic tissue damage and repair in a reproducible and quantifiable manner. These examples relate to the repair of bone fracture, skin wounds, and limb ischemia.
AB - In order to develop new therapies for tissue regeneration, experimentation in nonhuman animals is fundamental. To a great extent, animal models serve as the link between in vitro stem cell manipulation and synthesis of products, such as synthetic matrices and organs, and clinical application. Animal models are indeed the basic tool to evaluate biosafety and efficacy of new technologies prior to their application in human patients and these models contribute greatly to our understanding of the underlying mechanisms involved in the regenerative process. In this chapter, we outline important rodent models used in the field of tissue repair, highlighting key immune-deficient mouse strains for transplantation of human stem cells. We also present examples of methods to be used in mice to mimic tissue damage and repair in a reproducible and quantifiable manner. These examples relate to the repair of bone fracture, skin wounds, and limb ischemia.
KW - Blood Flow Restoration
KW - Fracture Apparatus
KW - Hind Limb Ischemia Model
KW - Human Duchenne Muscular Dystrophy
KW - Human Stem Cell
UR - https://www.scopus.com/pages/publications/105009432489
U2 - 10.1007/978-1-61779-322-6_20
DO - 10.1007/978-1-61779-322-6_20
M3 - Chapter
AN - SCOPUS:105009432489
T3 - Stem Cell Biology and Regenerative Medicine
SP - 379
EP - 391
BT - Stem Cell Biology and Regenerative Medicine
PB - Springer Nature
ER -
