Slow persistent infection caused by visna virus: Role of host restriction

Ashley T. Haase; Linda Stowring; Opendra Narayan; Dianne Griffin; Donald Price

doi:10.1126/science.188133

Slow persistent infection caused by visna virus: Role of host restriction

Ashley T. Haase, Linda Stowring, Opendra Narayan, Dianne Griffin, Donald Price

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

Proviral DNA has been demonstrated by in situ hybridization in foci of cells of a lamb infected with the RNA slow virus visna. A few of these cells also contain the major virion structural antigen p30. This restriction in virus gene expression in the infected animal provides a mechanism for persistence of virus in this chronic infection.

Original language	English
Pages (from-to)	175-177
Number of pages	3
Journal	Science
Volume	195
Issue number	4274
DOIs	https://doi.org/10.1126/science.188133
State	Published - 1977
Externally published	Yes

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@article{869282638bc146a49f35249b60c26f92,

title = "Slow persistent infection caused by visna virus: Role of host restriction",

abstract = "Proviral DNA has been demonstrated by in situ hybridization in foci of cells of a lamb infected with the RNA slow virus visna. A few of these cells also contain the major virion structural antigen p30. This restriction in virus gene expression in the infected animal provides a mechanism for persistence of virus in this chronic infection.",

author = "Haase, {Ashley T.} and Linda Stowring and Opendra Narayan and Dianne Griffin and Donald Price",

year = "1977",

doi = "10.1126/science.188133",

language = "English",

volume = "195",

pages = "175--177",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

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T1 - Slow persistent infection caused by visna virus

T2 - Role of host restriction

AU - Haase, Ashley T.

AU - Stowring, Linda

AU - Narayan, Opendra

AU - Griffin, Dianne

AU - Price, Donald

PY - 1977

Y1 - 1977

N2 - Proviral DNA has been demonstrated by in situ hybridization in foci of cells of a lamb infected with the RNA slow virus visna. A few of these cells also contain the major virion structural antigen p30. This restriction in virus gene expression in the infected animal provides a mechanism for persistence of virus in this chronic infection.

AB - Proviral DNA has been demonstrated by in situ hybridization in foci of cells of a lamb infected with the RNA slow virus visna. A few of these cells also contain the major virion structural antigen p30. This restriction in virus gene expression in the infected animal provides a mechanism for persistence of virus in this chronic infection.

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U2 - 10.1126/science.188133

DO - 10.1126/science.188133

M3 - Article

C2 - 188133

AN - SCOPUS:0017577407

SN - 0036-8075

VL - 195

SP - 175

EP - 177

JO - Science

JF - Science

IS - 4274

ER -

Slow persistent infection caused by visna virus: Role of host restriction

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