Skin surface pH, stratum corneum hydration, trans-epidermal water loss and skin roughness related to atopic eczema and skin dryness in a population of primary school children

B. Eberlein-Konig, T. Schafer, J. Huss-Marp, U. Darsow, M. Mohrenschlager, O. Herbert, D. Abeck, U. Kramer, H. Behrendt, J. Ring

Research output: Contribution to journalArticlepeer-review

196 Scopus citations

Abstract

Non-invasive investigations of skin morphology and function are standard tools to study the pathophysiology of several cutaneous disorders, yet they have not been used in population-based epidemiological studies. Here we examined skin surface pH, stratum corneum hydration, trans-epidermal water loss (TEWL) and skin roughness by profilometry in a study · population comprising 377 primary school children (8-9 years old) as part of a multicentre survey on risk factors for allergic diseases in school children. Skin surface pH showed significant higher values (p=0.029) in the group with atopic eczema (n=45) compared with the group without atopic eczema; all other parameters did not differ significantly between children with and without atopic eczema. With increasing skin dryness there was a significant increase in pH values (p=0.004). Stratum corneum hydration showed a significant decrease with increasing dryness (p < 0.001). Measurement of skin roughness also revealed a significant linear relationship with skin dryness (p=0.02). It is concluded that measurement of skin surface pH, corneometry and profilometry are useful non-invasive techniques to objectively assess skin dryness in epidemiological studies regarding atopic skin disease.

Original languageEnglish
Pages (from-to)188-191
Number of pages4
JournalActa Dermato-Venereologica
Volume80
Issue number3
DOIs
StatePublished - 2000

Keywords

  • Cutaneous properties
  • Epidemiological study
  • MIRIAM (Multicentre International Study for Risk Assessment of Indoor and Outdoor-Air Pollution on Allergy and Eczema Morbidity)
  • Non-invasive technologies
  • Skin morphology

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