TY - GEN
T1 - Single-energy material decomposition with grating-based x-ray phase-contrast CT
AU - Braig, Eva Maria
AU - Dierolf, Martin
AU - Guenther, Benedikt
AU - Mechlem, Korbinian
AU - Allner, Sebastian
AU - Sellerer, Thorsten
AU - Achterhold, Klaus
AU - Gleich, Bernhard
AU - Rummeny, Ernst
AU - Pfeiffer, Daniela
AU - Pfeiffer, Franz
AU - Herzen, Julia
N1 - Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.
PY - 2019
Y1 - 2019
N2 - In clinical X-ray imaging, the quantitative information in a CT scan has recently been extended by the possibility of using dual-energy information. Dual-energy CT has found its way into clinical imaging during the last few years and has been proven to add additional diagnostic information in different pathologies. It is based on a dual measurement at different photon energies, such that the energy dependence of the linear attenuation coefficient can be used for improved material discrimination. Here, we demonstrate how the dual information accessed with grating-based phase-contrast CT can be used to provide the same quantitative information. Different from dual energy, the phase-contrast measurement directly yields the electron-density and the total attenuation coefficient in a single measurement. With algebraic basis transformation this can be used for quantitative material decomposition, allowing the visualization of quantitative material maps. Further, a simple interaction parametrization has been used for the generation of effective atomic number maps and virtual monochromatic images. The approach has been demonstrated with an experimental angiography simulation with a chicken heart. The results have been compared with iodine staining, which is a current approach for ex-vivo soft-tissue contrast enhancement. The measurements have been performed at a compact laser-undulator synchrotron X-ray source with a tunable quasi-monochromatic X-ray energy. The simultaneous image acquisition guarantees an inherent registration of the two original data-sets. In total, the method provides a range of novel quantitative image representations which can be helpful for specific material discrimination tasks in medical imaging in the future.
AB - In clinical X-ray imaging, the quantitative information in a CT scan has recently been extended by the possibility of using dual-energy information. Dual-energy CT has found its way into clinical imaging during the last few years and has been proven to add additional diagnostic information in different pathologies. It is based on a dual measurement at different photon energies, such that the energy dependence of the linear attenuation coefficient can be used for improved material discrimination. Here, we demonstrate how the dual information accessed with grating-based phase-contrast CT can be used to provide the same quantitative information. Different from dual energy, the phase-contrast measurement directly yields the electron-density and the total attenuation coefficient in a single measurement. With algebraic basis transformation this can be used for quantitative material decomposition, allowing the visualization of quantitative material maps. Further, a simple interaction parametrization has been used for the generation of effective atomic number maps and virtual monochromatic images. The approach has been demonstrated with an experimental angiography simulation with a chicken heart. The results have been compared with iodine staining, which is a current approach for ex-vivo soft-tissue contrast enhancement. The measurements have been performed at a compact laser-undulator synchrotron X-ray source with a tunable quasi-monochromatic X-ray energy. The simultaneous image acquisition guarantees an inherent registration of the two original data-sets. In total, the method provides a range of novel quantitative image representations which can be helpful for specific material discrimination tasks in medical imaging in the future.
KW - Dual-energy CT
KW - Material decomposition
KW - Quantitative iodine maps
KW - Soft-tissue staining
KW - Talbot-Lau grating interferometry
KW - X-ray phase-contrast
UR - http://www.scopus.com/inward/record.url?scp=85077788453&partnerID=8YFLogxK
U2 - 10.1117/12.2528384
DO - 10.1117/12.2528384
M3 - Conference contribution
AN - SCOPUS:85077788453
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - Developments in X-Ray Tomography XII
A2 - Muller, Bert
A2 - Wang, Ge
PB - SPIE
T2 - 12th SPIE Conference on Developments in X-Ray Tomography 2019
Y2 - 13 August 2019 through 15 August 2019
ER -