Single amino acid substitutions in conserved extracellular domains of E-cadherin differ in their functional consequences

Keyphrases

• Functional Consequences 100%
• E-cadherin 100%
• Extracellular Domain 100%
• Single Amino Acid Substitution 100%
• Cell Adhesion 50%
• Cell Motility 50%
• Cell Morphology 25%
• Loss Function 25%
• Sequence Modification 25%
• Complementary DNA (cDNA) 25%
• Gain-of-function 25%
• Structure Function 25%
• Tumor Cells 25%
• Sequence Coding 25%
• Epithelial Cells 25%
• Mammary Carcinoma Cells 25%
• Gene Family 25%
• Transmembrane Protein 25%
• Cytoskeleton 25%
• Cell Adhesion Molecules 25%
• Functional Significance 25%
• Linker Region 25%
• Protein Localization 25%
• Calcium-dependent 25%
• Gastric Cancer 25%
• Gastric Cancer Patients 25%
• MDA-MB-435S 25%
• Calcium Binding 25%
• Cadherin 25%
• Calcium Binding Site 25%
• Similar Sequences 25%
• Third Domain 25%
• Amino Acid Motifs 25%
• Patient mutations 25%
• Tumor-associated 25%
• Abnormal Proteins 25%

Biochemistry, Genetics and Molecular Biology

• Amino Acid Substitution 100%
• Cadherin 100%
• Cell Migration 40%
• Cell Adhesion 40%
• Cell Motility 40%
• Calcium Binding 40%
• Wild Type 20%
• Cell Adhesion Proteins 20%
• Cytoskeleton 20%
• Multigene Family 20%
• Gene Mutation 20%
• Protein Motif 20%
• Induced Mutation 20%
• Actin 20%
• Membrane Protein 20%
• Transmembrane Protein 20%

Immunology and Microbiology

• Amino Acid Substitution 100%
• Cadherin 100%
• Cell Adhesion 40%
• Cell Motility 40%
• Calcium Binding 40%
• Cell Migration 40%
• Cytoskeleton 20%
• Tumor Cell 20%
• Gene Mutation 20%
• Multigene Family 20%
• Protein Motif 20%
• Carcinoma Cell 20%
• Induced Mutation 20%
• Cell Adhesion Proteins 20%
• Wild Type 20%
• Actin 20%