Simultaneous electroencephalographic and functional magnetic resonance imaging indicate impaired cortical top-down processing in association with anesthetic-induced unconsciousness

Deni Jordan, Rüdige Ilg, Valenti Riedl, Ann Schorer, Sabin Grimberg, Susann Neufang, Ade Omerovic, Sebastia Berger, Gisel Untergehrer, Christin Preibisch, Enric Schulz, Tibo Schuster, Manue Schröter, Victo Spoormaker, Clau Zimmer, Bernhar Hemmer, Afr Wohlschläger, Eberhar F. Kochs, Gerhar Schneider

Research output: Contribution to journalArticlepeer-review

144 Scopus citations

Abstract

Background: In imaging functional connectivity (FC) analyses of the resting brain, alterations of FC during unconsciousness have been reported. These results are in accordance with recent electroencephalographic studies observing impaired top-down processing during anesthesia. In this study, simultaneous records of functional magnetic resonance imaging between underlying physiological processes. The relationship (fMRI) and electroencephalogram were performed to investigate the causality of neural mechanisms during propofolinduced loss of consciousness by correlating FC in fMRI and directional connectivity (DC) in electroencephalogram. Methods: Resting-state 63-channel electroencephalogram and blood oxygen level-dependent 3-Tesla fMRI of 15 healthy subjects were simultaneously registered during consciousness and propofol-induced loss of consciousness. To indicate DC, electroencephalographic symbolic transfer entropy was applied as a nonlinear measure of mutual interdependencies between FC of resting-state networks of the brain (z values) and DC was analyzed by a partial correlation. Results: Independent component analyses of resting-state fMRI showed decreased FC in frontoparietal default networks during unconsciousness, whereas FC in primary sensory networks increased. DC indicated a decline in frontal-parietal (area under the receiver characteristic curve, 0.92; 95% CI, 0.68-1.00) and frontooccipital (0.82; 0.53-1.00) feedback DC (P < 0.05 corrected). The changes of FC in the anterior default network correlated with the changes of DC in frontal-parietal (rpartial = +0.62; P = 0.030) and frontal-occipital (+0.63; 0.048) electroencephalographic electrodes (P < 0.05 corrected). Conclusion: The simultaneous propofol-induced suppression of frontal feedback connectivity in the electroencephalogram and of frontoparietal FC in the fMRI indicates a fundamental role of top-down processing for consciousness.

Original languageEnglish
Pages (from-to)1031-1042
Number of pages12
JournalAnesthesiology
Volume119
Issue number5
DOIs
StatePublished - Nov 2013
Externally publishedYes

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