Simulation of the structure and dynamics of nonhelical RNA motifs

Martin Zacharias

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

Computer simulation methods are increasingly being used to study possible conformations and dynamics of structural motifs in RNA. Recent results of molecular dynamics simulations and continuum solvent studies of RNA structures and RNA-ligand complexes show promising agreement with experimental data. Combined with the ongoing progress in the experimental characterization of RNA structure and thermodynamics. these computational approaches can help to better understand the mechanism of RNA structure formation and the binding of ligands.

Original languageEnglish
Pages (from-to)311-317
Number of pages7
JournalCurrent Opinion in Structural Biology
Volume10
Issue number3
DOIs
StatePublished - 1 Jun 2000
Externally publishedYes

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