Abstract
Tendons and tendon-to-bone entheses are frequent injury sites among athletes, accounting for up to 50% of all sports-related injuries. Additionally, about 2%–5% of the general population is affected by tendinopathies up to some degree due to overuse, sport-related injuries, and/or degeneration. This situation is likely to worsen in the coming years due to the increasing popularity of sports practice among the middle-aged and elderly population. Unfortunately, the success rate of clinical intervention to treat tendinopathies is far from desirable, with surgical repair failure rates ranging from 20% to 90% in many cases. In this chapter, we review the perspective of tissue engineering to tackle the challenge that represents the successful treatment of injured tendon/enthesis. Furthermore, we look into the potential use of silk biomaterials in tendon and enthesis tissue engineering.
Original language | English |
---|---|
Title of host publication | Silk-Based Biomaterials for Tissue Engineering, Regenerative, and Precision Medicine, 2nd Edition |
Publisher | Elsevier |
Pages | 549-565 |
Number of pages | 17 |
ISBN (Electronic) | 9780323960175 |
ISBN (Print) | 9780323960168 |
DOIs | |
State | Published - 1 Jan 2023 |
Externally published | Yes |
Keywords
- Enthesis
- fibroin
- ligament
- musculoskeletal
- silk
- tendon