Silk biomaterials for tendon and tendon-to-bone enthesis tissue engineering

Carlos Julio Peniche Silva, Elizabeth Rosado Balmayor, Martijn van Griensven

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Tendons and tendon-to-bone entheses are frequent injury sites among athletes, accounting for up to 50% of all sports-related injuries. Additionally, about 2%–5% of the general population is affected by tendinopathies up to some degree due to overuse, sport-related injuries, and/or degeneration. This situation is likely to worsen in the coming years due to the increasing popularity of sports practice among the middle-aged and elderly population. Unfortunately, the success rate of clinical intervention to treat tendinopathies is far from desirable, with surgical repair failure rates ranging from 20% to 90% in many cases. In this chapter, we review the perspective of tissue engineering to tackle the challenge that represents the successful treatment of injured tendon/enthesis. Furthermore, we look into the potential use of silk biomaterials in tendon and enthesis tissue engineering.

Original languageEnglish
Title of host publicationSilk-Based Biomaterials for Tissue Engineering, Regenerative, and Precision Medicine, 2nd Edition
PublisherElsevier
Pages549-565
Number of pages17
ISBN (Electronic)9780323960175
ISBN (Print)9780323960168
DOIs
StatePublished - 1 Jan 2023
Externally publishedYes

Keywords

  • Enthesis
  • fibroin
  • ligament
  • musculoskeletal
  • silk
  • tendon

Fingerprint

Dive into the research topics of 'Silk biomaterials for tendon and tendon-to-bone enthesis tissue engineering'. Together they form a unique fingerprint.

Cite this