TY - JOUR
T1 - Signaling to extracellular signal-regulated kinase from erbb1 kinase and protein kinase c
T2 - Feedback, heterogeneity, and gating
AU - Perrett, Rebecca M.
AU - Fowkes, Robert C.
AU - Caunt, Christopher J.
AU - Tsaneva-Atanasova, Krasimira
AU - Bowsher, Clive G.
AU - McArdle, Craig A.
PY - 2013/7/19
Y1 - 2013/7/19
N2 - Background: The mechanisms underlying acute ERK signaling are poorly understood. Results: Feedback influences basal and acutely stimulated ERK responses but does not render signaling kinetics robust to ERK concentration. Conclusion: Acute ERK response kinetics depend on ERK concentration and activation mechanism as well as feedback. Significance: ERK responses to transient stimulation can be gated by ERK concentration, and short-term activation appears distributive rather than processive.
AB - Background: The mechanisms underlying acute ERK signaling are poorly understood. Results: Feedback influences basal and acutely stimulated ERK responses but does not render signaling kinetics robust to ERK concentration. Conclusion: Acute ERK response kinetics depend on ERK concentration and activation mechanism as well as feedback. Significance: ERK responses to transient stimulation can be gated by ERK concentration, and short-term activation appears distributive rather than processive.
UR - http://www.scopus.com/inward/record.url?scp=84880538437&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.455345
DO - 10.1074/jbc.M113.455345
M3 - Article
C2 - 23754287
AN - SCOPUS:84880538437
SN - 0021-9258
VL - 288
SP - 21001
EP - 21014
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 29
ER -