Seven-transmembrane receptor signalling and ERK compartmentalization

Christopher J. Caunt, Ann R. Finch, Kathleen R. Sedgley, Craig A. McArdle

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations


Vast numbers of extracellular signalling molecules exert effects on their target cells by activation of a relatively limited number of mitogen-activated protein kinase (MAPK) cascades, raising the question of how specificity is achieved. To a large extent, this appears to be attributable to differences in kinetics and compartmentalization of MAPK protein activation that are dictated by MAPK-associated proteins serving as scaffolds, anchors, activators or effectors. Here, we review spatiotemporal aspects of signalling via the Ras-Raf-extracellular signal-regulated kinase pathway, emphasizing recent work on roles of arrestins as scaffolds and transducers for seven transmembrane receptor signalling.

Original languageEnglish
Pages (from-to)276-283
Number of pages8
JournalTrends in Endocrinology and Metabolism
Issue number7
StatePublished - Sep 2006
Externally publishedYes


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