Serum uromodulin predicts graft failure in renal transplant recipients

Dominik Steubl; Matthias Block; Victor Herbst; Wolfgang Schlumberger; Andreas Nockher; Susanne Angermann; Christoph Schmaderer; Uwe Heemann; Lutz Renders; Jürgen Scherberich

doi:10.1080/1354750X.2016.1252957

Serum uromodulin predicts graft failure in renal transplant recipients

Dominik Steubl, Matthias Block, Victor Herbst, Wolfgang Schlumberger, Andreas Nockher, Susanne Angermann, Christoph Schmaderer, Uwe Heemann, Lutz Renders, Jürgen Scherberich

Associate Professorship of Nephrology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Objective and methods: Test the ability of serum uromodulin concentrations 1–3 months after renal transplantation to predict all-cause mortality (ACM) and graft loss (GL) in 91 patients. Results: uromodulin predicted GL equivalently to the other markers studied: the risk for GL was reduced by 0.21 per one standard deviation (SD) increase (cystatin C: hazard ratio [HR] 4.57, creatinine: HR 4.53, blood-urea-nitrogen [BUN]: HR 2.50, estimated glomerular filtration rate [eGFR]: HR 0.10). In receiver-operating-characteristic (ROC) analysis, uromodulin predicted GL with an area-under-the curve of 0.782 at an optimal cut-off (OCO) of 24.0 ng/ml with a sensitivity of 90.0% and a specificity of 70.2%. Conclusion: Serum uromodulin predicted GL equivalently compared to conventional biomarkers of glomerular filtration.

Original language	English
Pages (from-to)	171-177
Number of pages	7
Journal	Biomarkers
Volume	22
Issue number	2
DOIs	https://doi.org/10.1080/1354750X.2016.1252957
State	Published - 17 Feb 2017

Keywords

Biomarker
Tamm–Horsfall protein
cystatin C
eGFR
graft failure
kidney transplantation
proteinuria
uromodulin

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title = "Serum uromodulin predicts graft failure in renal transplant recipients",

abstract = "Objective and methods: Test the ability of serum uromodulin concentrations 1–3 months after renal transplantation to predict all-cause mortality (ACM) and graft loss (GL) in 91 patients. Results: uromodulin predicted GL equivalently to the other markers studied: the risk for GL was reduced by 0.21 per one standard deviation (SD) increase (cystatin C: hazard ratio [HR] 4.57, creatinine: HR 4.53, blood-urea-nitrogen [BUN]: HR 2.50, estimated glomerular filtration rate [eGFR]: HR 0.10). In receiver-operating-characteristic (ROC) analysis, uromodulin predicted GL with an area-under-the curve of 0.782 at an optimal cut-off (OCO) of 24.0 ng/ml with a sensitivity of 90.0\% and a specificity of 70.2\%. Conclusion: Serum uromodulin predicted GL equivalently compared to conventional biomarkers of glomerular filtration.",

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AU - Herbst, Victor

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AU - Angermann, Susanne

AU - Schmaderer, Christoph

AU - Heemann, Uwe

AU - Renders, Lutz

AU - Scherberich, Jürgen

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N2 - Objective and methods: Test the ability of serum uromodulin concentrations 1–3 months after renal transplantation to predict all-cause mortality (ACM) and graft loss (GL) in 91 patients. Results: uromodulin predicted GL equivalently to the other markers studied: the risk for GL was reduced by 0.21 per one standard deviation (SD) increase (cystatin C: hazard ratio [HR] 4.57, creatinine: HR 4.53, blood-urea-nitrogen [BUN]: HR 2.50, estimated glomerular filtration rate [eGFR]: HR 0.10). In receiver-operating-characteristic (ROC) analysis, uromodulin predicted GL with an area-under-the curve of 0.782 at an optimal cut-off (OCO) of 24.0 ng/ml with a sensitivity of 90.0% and a specificity of 70.2%. Conclusion: Serum uromodulin predicted GL equivalently compared to conventional biomarkers of glomerular filtration.

AB - Objective and methods: Test the ability of serum uromodulin concentrations 1–3 months after renal transplantation to predict all-cause mortality (ACM) and graft loss (GL) in 91 patients. Results: uromodulin predicted GL equivalently to the other markers studied: the risk for GL was reduced by 0.21 per one standard deviation (SD) increase (cystatin C: hazard ratio [HR] 4.57, creatinine: HR 4.53, blood-urea-nitrogen [BUN]: HR 2.50, estimated glomerular filtration rate [eGFR]: HR 0.10). In receiver-operating-characteristic (ROC) analysis, uromodulin predicted GL with an area-under-the curve of 0.782 at an optimal cut-off (OCO) of 24.0 ng/ml with a sensitivity of 90.0% and a specificity of 70.2%. Conclusion: Serum uromodulin predicted GL equivalently compared to conventional biomarkers of glomerular filtration.

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Serum uromodulin predicts graft failure in renal transplant recipients

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