Sequential expression of JUN B, JUN D and FOS B proteins in rat spinal neurons: Cascade of transcriptional operations during nociception

Thomas Herdegen, Thomas R. Tölle, Rodrigo Bravo, Walter Zieglgänsberger, Manfred Zimmermann

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Expression of the immediate-early gene encoded proteins JUN B, JUN D and FOS B was investigated by immunocytochemistry in rat L5 spinal cord up to 24 h following stimulation of hind limb somatosensory nociceptors by noxious heat or injection of formalin. In both experimental protocols, JUN B, which did not show basal expression, reached maximum expression after 2 h and thereafter slowly decreased. In contrast, the expression of JUN D, which was present before stimulation in many spinal neurons, was increased after 4 h, reached its maximum after 8 h and thereafter remained elevated. FOS B which was absent under basal conditions reached its maximum between 4 h and 8 h and thereafter declined but was still present after 24 h. All immunoreactivities were restricted to the ipsilateral dorsal horn except JUN D which was also induced in the contralateral side after 8 h. The results are discussed in respect to their meaning for transcriptional operations of JUN and FOS proteins.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalNeuroscience Letters
Volume129
Issue number2
DOIs
StatePublished - 19 Aug 1991
Externally publishedYes

Keywords

  • FOS B
  • JUN B
  • JUN D
  • acute formalin inflammation
  • nociception
  • noxious heat
  • rat CNS
  • spinal cord

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