Sequence- and structure-based analysis of tissue-specific phosphorylation sites

Nermin Pinar Karabulut, Dmitrij Frishman

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Phosphorylation is the most widespread and well studied reversible posttranslational modification. Discovering tissue-specific preferences of phosphorylation sites is important as phosphorylation plays a role in regulating almost every cellular activity and disease state. Here we present a comprehensive analysis of global and tissue-specific sequence and structure properties of phosphorylation sites utilizing recent proteomics data. We identified tissue-specific motifs in both sequence and spatial environments of phosphorylation sites. Target site preferences of kinases across tissues indicate that, while many kinases mediate phosphorylation in all tissues, there are also kinases that exhibit more tissue-specific preferences which, notably, are not caused by tissue-specific kinase expression. We also demonstrate that many metabolic pathways are differentially regulated by phosphorylation in different tissues.

Original languageEnglish
Article numbere0157896
JournalPLoS ONE
Volume11
Issue number6
DOIs
StatePublished - Jun 2016
Externally publishedYes

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