Self-supervised Learning for Physiologically-Based Pharmacokinetic Modeling in Dynamic PET

Francesca De Benetti, Walter Simson, Magdalini Paschali, Hasan Sari, Axel Rominger, Kuangyu Shi, Nassir Navab, Thomas Wendler

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

Dynamic Positron Emission Tomography imaging (dPET) provides temporally resolved images of a tracer. Voxel-wise physiologically-based pharmacokinetic modeling of the Time Activity Curves (TAC) extracted from dPET can provide relevant diagnostic information for clinical workflow. Conventional fitting strategies for TACs are slow and ignore the spatial relation between neighboring voxels. We train a spatio-temporal UNet to estimate the kinetic parameters given TAC from dPET. This work introduces a self-supervised loss formulation to enforce the similarity between the measured TAC and those generated with the learned kinetic parameters. Our method provides quantitatively comparable results at organ level to the significantly slower conventional approaches while generating pixel-wise kinetic parametric images which are consistent with expected physiology. To the best of our knowledge, this is the first self-supervised network that allows voxel-wise computation of kinetic parameters consistent with a non-linear kinetic model.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer Assisted Intervention – MICCAI 2023 - 26th International Conference, Proceedings
EditorsHayit Greenspan, Hayit Greenspan, Anant Madabhushi, Parvin Mousavi, Septimiu Salcudean, James Duncan, Tanveer Syeda-Mahmood, Russell Taylor
PublisherSpringer Science and Business Media Deutschland GmbH
Pages290-299
Number of pages10
ISBN (Print)9783031439063
DOIs
StatePublished - 2023
Event26th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2023 - Vancouver, Canada
Duration: 8 Oct 202312 Oct 2023

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume14220 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference26th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2023
Country/TerritoryCanada
CityVancouver
Period8/10/2312/10/23

Keywords

  • Dynamic PET
  • Kinetic modelling
  • PBPK models

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