@inproceedings{42eaecb550af4b35a03c1c85786e6f9e,
title = "Self-supervised Learning for Physiologically-Based Pharmacokinetic Modeling in Dynamic PET",
abstract = "Dynamic Positron Emission Tomography imaging (dPET) provides temporally resolved images of a tracer. Voxel-wise physiologically-based pharmacokinetic modeling of the Time Activity Curves (TAC) extracted from dPET can provide relevant diagnostic information for clinical workflow. Conventional fitting strategies for TACs are slow and ignore the spatial relation between neighboring voxels. We train a spatio-temporal UNet to estimate the kinetic parameters given TAC from dPET. This work introduces a self-supervised loss formulation to enforce the similarity between the measured TAC and those generated with the learned kinetic parameters. Our method provides quantitatively comparable results at organ level to the significantly slower conventional approaches while generating pixel-wise kinetic parametric images which are consistent with expected physiology. To the best of our knowledge, this is the first self-supervised network that allows voxel-wise computation of kinetic parameters consistent with a non-linear kinetic model.",
keywords = "Dynamic PET, Kinetic modelling, PBPK models",
author = "{De Benetti}, Francesca and Walter Simson and Magdalini Paschali and Hasan Sari and Axel Rominger and Kuangyu Shi and Nassir Navab and Thomas Wendler",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.; 26th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2023 ; Conference date: 08-10-2023 Through 12-10-2023",
year = "2023",
doi = "10.1007/978-3-031-43907-0_28",
language = "English",
isbn = "9783031439063",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "290--299",
editor = "Hayit Greenspan and Hayit Greenspan and Anant Madabhushi and Parvin Mousavi and Septimiu Salcudean and James Duncan and Tanveer Syeda-Mahmood and Russell Taylor",
booktitle = "Medical Image Computing and Computer Assisted Intervention – MICCAI 2023 - 26th International Conference, Proceedings",
}