TY - JOUR
T1 - Selectively N-methylated soluble IAPP mimics as potent IAPP receptor agonists and nanomolar inhibitors of cytotoxic self-assembly of both IAPP and Aβ40
AU - Yan, Li Mei
AU - Velkova, Aleksandra
AU - Tatarek-Nossol, Marianna
AU - Rammes, Gerhard
AU - Sibaev, Andrei
AU - Andreetto, Erika
AU - Kracklauer, Michael
AU - Bakou, Maria
AU - Malideli, Eleni
AU - Göke, Burkhard
AU - Schirra, Jörg
AU - Storr, Martin
AU - Kapurniotu, Aphrodite
PY - 2013/9/23
Y1 - 2013/9/23
N2 - The selective incorporation of N-methyl groups in the highly amyloidogenic and cytotoxic sequence of the type 2 diabetes islet amyloid polypeptide (IAPP) generates a unique class of soluble and nontoxic IAPP mimics. These polypeptides combine potent IAPP receptor agonism with nanomolar-affinity inhibitory potential on the amyloid formation and cell-damaging effects of both IAPP and the Alzheimer's β-amyloid peptide (Aβ40).
AB - The selective incorporation of N-methyl groups in the highly amyloidogenic and cytotoxic sequence of the type 2 diabetes islet amyloid polypeptide (IAPP) generates a unique class of soluble and nontoxic IAPP mimics. These polypeptides combine potent IAPP receptor agonism with nanomolar-affinity inhibitory potential on the amyloid formation and cell-damaging effects of both IAPP and the Alzheimer's β-amyloid peptide (Aβ40).
KW - IAPP receptor agonist
KW - islet amyloid polypeptide
KW - protein interactions
KW - self-assembly
KW - β-amyloid peptide
UR - http://www.scopus.com/inward/record.url?scp=84884844389&partnerID=8YFLogxK
U2 - 10.1002/anie.201302840
DO - 10.1002/anie.201302840
M3 - Article
C2 - 23956012
AN - SCOPUS:84884844389
SN - 1433-7851
VL - 52
SP - 10378
EP - 10383
JO - Angewandte Chemie International Edition in English
JF - Angewandte Chemie International Edition in English
IS - 39
ER -