Selective RGD-mediated adhesion of osteoblasts at surfaces of implants

Martin Kantlehner; Dirk Finsinger; Jörg Meyer; Patricia Schaffner; Alfred Jonczyk; Beate Diefenbach; Berthold Nies; Horst Kessler

doi:10.1002/(SICI)1521-3773(19990215)38:4<560::AID-ANIE560>3.0.CO;2-F

Selective RGD-mediated adhesion of osteoblasts at surfaces of implants

Martin Kantlehner
, Dirk Finsinger
, Jörg Meyer
, Patricia Schaffner
, Alfred Jonczyk
, Beate Diefenbach
, Berthold Nies
, Horst Kessler

TUM Emeriti of Excellence

Technical University of Munich
Merck KGaA

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

Osteoblasts: yes, platelets: no! Bone implants have to be integrated with the surrounding tissue to allow a smooth and stable connection. A new procedure is shown which is based on covalent linking of a highly selective RGD peptide to a poly(methyl methacrylate) (PMMA) material (see picture). Osteoblasts very effectively bind to the treated surface and are stimulated to proliferate.

Original language	English
Pages (from-to)	560-562
Number of pages	3
Journal	Angewandte Chemie International Edition in English
Volume	38
Issue number	4
DOIs	https://doi.org/10.1002/(SICI)1521-3773(19990215)38:4<560::AID-ANIE560>3.0.CO;2-F
State	Published - 15 Feb 1999

Keywords

Bioorganic chemistry
Integrins
Materials science
Peptides
Surface chemistry

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10.1002/(SICI)1521-3773(19990215)38:4<560::AID-ANIE560>3.0.CO;2-F

Cite this

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title = "Selective RGD-mediated adhesion of osteoblasts at surfaces of implants",

abstract = "Osteoblasts: yes, platelets: no! Bone implants have to be integrated with the surrounding tissue to allow a smooth and stable connection. A new procedure is shown which is based on covalent linking of a highly selective RGD peptide to a poly(methyl methacrylate) (PMMA) material (see picture). Osteoblasts very effectively bind to the treated surface and are stimulated to proliferate.",

keywords = "Bioorganic chemistry, Integrins, Materials science, Peptides, Surface chemistry",

author = "Martin Kantlehner and Dirk Finsinger and J{\"o}rg Meyer and Patricia Schaffner and Alfred Jonczyk and Beate Diefenbach and Berthold Nies and Horst Kessler",

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T1 - Selective RGD-mediated adhesion of osteoblasts at surfaces of implants

AU - Kantlehner, Martin

AU - Finsinger, Dirk

AU - Meyer, Jörg

AU - Schaffner, Patricia

AU - Jonczyk, Alfred

AU - Diefenbach, Beate

AU - Nies, Berthold

AU - Kessler, Horst

PY - 1999/2/15

Y1 - 1999/2/15

N2 - Osteoblasts: yes, platelets: no! Bone implants have to be integrated with the surrounding tissue to allow a smooth and stable connection. A new procedure is shown which is based on covalent linking of a highly selective RGD peptide to a poly(methyl methacrylate) (PMMA) material (see picture). Osteoblasts very effectively bind to the treated surface and are stimulated to proliferate.

AB - Osteoblasts: yes, platelets: no! Bone implants have to be integrated with the surrounding tissue to allow a smooth and stable connection. A new procedure is shown which is based on covalent linking of a highly selective RGD peptide to a poly(methyl methacrylate) (PMMA) material (see picture). Osteoblasts very effectively bind to the treated surface and are stimulated to proliferate.

KW - Bioorganic chemistry

KW - Integrins

KW - Materials science

KW - Peptides

KW - Surface chemistry

UR - https://www.scopus.com/pages/publications/0033557411

U2 - 10.1002/(SICI)1521-3773(19990215)38:4<560::AID-ANIE560>3.0.CO;2-F

DO - 10.1002/(SICI)1521-3773(19990215)38:4<560::AID-ANIE560>3.0.CO;2-F

M3 - Article

AN - SCOPUS:0033557411

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JO - Angewandte Chemie International Edition in English

JF - Angewandte Chemie International Edition in English

IS - 4

ER -

Selective RGD-mediated adhesion of osteoblasts at surfaces of implants

Abstract

Keywords

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