Selective reduction of amides to amines by boronic acid catalyzed hydrosilylation

Yuehui Li, Jesús A. Molina De La Torre, Kathleen Grabow, Ursula Bentrup, Kathrin Junge, Shaolin Zhou, Angelika Brückner, Matthias Beller

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

Not a 'B'ore! Benzothiophene-based boronic acids catalyze the reduction of tertiary, secondary, and primary amides in the presence of a hydrosilane. The reaction demonstrates good functional-group tolerance.

Original languageEnglish
Pages (from-to)11577-11580
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume52
Issue number44
DOIs
StatePublished - 25 Oct 2013
Externally publishedYes

Keywords

  • amides
  • boron
  • homogeneous catalysis
  • organocatalysis
  • reduction

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