Selective Palladium-Catalyzed Aminocarbonylation of Olefins to Branched Amides

Jie Liu, Haoquan Li, Anke Spannenberg, Robert Franke, Ralf Jackstell, Matthias Beller

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

A general and efficient protocol for iso-selective aminocarbonylation of olefins with aliphatic amines has been developed for the first time. Key to the success for this process is the use of a specific 2-phosphino-substituted pyrrole ligand in the presence of PdX2(X=halide) as a pre-catalyst. Bulk industrial and functionalized olefins react with various aliphatic amines, including amino-acid derivatives, to give the corresponding branched amides generally in good yields (up to 99 %) and regioselectivities (b/l up to 99:1).

Original languageEnglish
Pages (from-to)13544-13548
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume55
Issue number43
DOIs
StatePublished - 17 Oct 2016
Externally publishedYes

Keywords

  • P ligands
  • amines
  • carbonylation
  • olefins
  • synthetic methodology

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