Selective palladium-catalyzed aminocarbonylation of 1,3-dienes: Atom-efficient synthesis of β,γ-unsaturated amides

Xianjie Fang, Haoquan Li, Ralf Jackstell, Matthias Beller

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Carbonylation reactions constitute important methodologies for the synthesis of all kinds of carboxylic acid derivatives. The development of novel and efficient catalysts for these transformations is of interest for both academic and industrial research. Here, the first palladium-based catalyst system for the aminocarbonylation of 1,3-dienes is described. This atom-efficient transformation proceeds under additive-free conditions and provides straightforward access to a variety of β,γ-unsaturated amides in good to excellent yields, often with high selectivities.

Original languageEnglish
Pages (from-to)16039-16043
Number of pages5
JournalJournal of the American Chemical Society
Volume136
Issue number45
DOIs
StatePublished - 12 Nov 2014
Externally publishedYes

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