Selective methylation of amines with carbon dioxide and H2

Yuehui Li, Iván Sorribes, Tao Yan, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

241 Scopus citations

Abstract

Put a label on it: Carbon dioxide with H2 is shown to be an efficient and selective methylation reagent for aromatic and aliphatic amines (see scheme; acac=acetylacetonate, triphos = 1,1,1- tris(diphenylphosphanylmethyl)ethane). A variety of functionalized amines including 13C-labelled drugs were obtained with good yields and functional-group tolerance.

Original languageEnglish
Pages (from-to)12156-12160
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume52
Issue number46
DOIs
StatePublished - 11 Nov 2013
Externally publishedYes

Keywords

  • homogeneous catalysis
  • hydrogen
  • methylation
  • reduction
  • ruthenium

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