Selective host-guest binding of anions without auxiliary hydrogen bonds: Entropy as an aid to design

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Abstract

Entropy matters! In contrast to classic host-guest design, which employs dedicated enthalpic interactions of the binding partners, the novel electroneutral host 1 binds its anionic guests by virtue of an overwhelmingly positive entropy of association. The prime driving force is guest desolvation. Despite the total omission of hydrogen bonding, host 1 is one of the best electroneutral receptors known for binding anions in polar solution.

Original languageEnglish
Pages (from-to)242-246
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume51
Issue number1
DOIs
StatePublished - 2 Jan 2012

Keywords

  • anions
  • cage compounds
  • calorimetry
  • enthalpy-entropy compensation
  • host-guest systems

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