Selective catalytic monoreduction of phthalimides and imidazolidine-2,4- diones

Shoubhik Das, Daniele Addis, Leif R. Knöpke, Ursula Bentrup, Kathrin Junge, Angelika Brückner, Matthias Beller

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

Fluoride's new role: Selective and efficient monoreductions of imides can be achieved with polymethylhydrosiloxane (PMHS) and tetra-n-butylammonium fluoride (TBAF) as catalyst (see scheme). The system is characterized by good chemoselectivity, operational simplicity, and functional-group tolerance; a concise mechanistic proposal was possible from in situ spectroscopic investigations.

Original languageEnglish
Pages (from-to)9180-9184
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume50
Issue number39
DOIs
StatePublished - 19 Sep 2011
Externally publishedYes

Keywords

  • amides
  • amines
  • fluorides
  • homogeneous catalysis
  • reduction

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