@inbook{0f9bd44e1f2c44338e79ae603e7fd45a,
title = "Selection and scheduling of pharmaceutical research projects",
abstract = "This paper deals with the lead optimization phase of pharmaceutical research where a number of leads (molecules as a basis for potential drugs) are processed by different departments in order to optimize their biochemical characteristics. We depict each lead as a project and model the problem as a static multi-project selection and scheduling problem under resource constraints with the objective to maximize the weighted work performed. For solving the problem we propose two heuristics. We assess their performance in a computational study and we point out one dominant method. Furthermore we show the impact of problem parameters such as the extend to which projects can be crashed.",
keywords = "Heuristics, Lead optimization, Multi-mode resource-constrained project scheduling, Pharmaceutical R&D",
author = "Rainer Kolisch and Konrad Meyer",
note = "Publisher Copyright: {\textcopyright} 2006, Springer New York LLC. All Rights Reserved.",
year = "2006",
language = "English",
series = "International Series in Operations Research and Management Science",
publisher = "Springer New York LLC",
pages = "321--344",
booktitle = "International Series in Operations Research and Management Science",
}