Scoring proteomes with proteotypic peptide probes

Bernhard Kuster, Markus Schirle, Parag Mallick, Ruedi Aebersold

Research output: Contribution to journalReview articlepeer-review

309 Scopus citations


Technologies for genome-wide analyses typically undergo a transition from a discovery phase to a scoring phase. In the discovery phase, the genomic universe is explored and all pertinent data are noted. In the scoring phase, relevant entities are screened to reveal groups of genes that are associated with specific biological processes or conditions. In this article, we propose that the transition from a discovery to a scoring phase is also essential, feasible and imminent for proteomics.

Original languageEnglish
Pages (from-to)577-583
Number of pages7
JournalNature Reviews Molecular Cell Biology
Issue number7
StatePublished - Jul 2005
Externally publishedYes


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