Scanning optoacoustic angiography for assessing structural and functional alterations in superficial vasculature of patients with post-thrombotic syndrome: A pilot study

Svetlana Nemirova, Anna Orlova, Alexey Kurnikov, Yulia Litvinova, Viacheslav Kazakov, Irina Ayvazyan, Yu Hang Liu, Daniel Razansky, Pavel Subochev

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

This study highlights the potential of scanning optoacoustic angiography (OA) in identifying alterations of superficial vasculature in patients with post-thrombotic syndrome (PTS) of the foot, a venous stress disorder associated with significant morbidity developing from long-term effects of deep venous thrombosis. The traditional angiography methods available in the clinics are not capable of reliably assessing the state of peripheral veins that provide blood outflow from the skin, a key hallmark of personalized risks of PTS formation after venous thrombosis. Our findings indicate that OA can detect an increase in blood volume, diameter, and tortuosity of superficial blood vessels. The inability to spatially separate vascular plexuses of the dermis and subcutaneous adipose tissue serves as a crucial criterion for distinguishing PTS from normal vasculature. Furthermore, our study demonstrates the ability of scanning optoacoustic angiography to detect blood filling decrease in an elevated limb position versus increase in a lowered position.

Original languageEnglish
Article number100616
JournalPhotoacoustics
Volume38
DOIs
StatePublished - Aug 2024
Externally publishedYes

Keywords

  • Functional tests
  • Post-thrombotic syndrome
  • Scanning optoacoustic angiography
  • Superficial vessels

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