Salt-free synthesis of tertiary amines by ruthenium-catalyzed amination of alcohols

Annegret Tillack, Dirk Hollmann, Kathleen Mevius, Dirk Michalik, Sebastian Bähn, Matthias Beller

Research output: Contribution to journalArticlepeer-review

107 Scopus citations

Abstract

The amination of secondary alcohols to give tertiary amines in the presence of different in situ generated ruthenium catalysts has been investigated in detail. By applying a combination of [Ru3(CO)12] and N-phenyl-2-(dicyclohexylphosphanyl) pyrrole as the catalyst, cyclic amines can be alkylated with different alcohols in high yield, whereas aliphatic amines gave transalkylation side products.

Original languageEnglish
Pages (from-to)4745-4750
Number of pages6
JournalEuropean Journal of Organic Chemistry
Issue number28
DOIs
StatePublished - Oct 2008
Externally publishedYes

Keywords

  • Alcohols
  • Amination
  • Ruthenium

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