S100 biomarkers in patients with traumatic brain injury

Henriette Beyer; Peter Biberthaler; Viktoria Bogner-Flatz

doi:10.1016/B978-0-12-816346-7.00010-5

S100 biomarkers in patients with traumatic brain injury

Henriette Beyer, Peter Biberthaler, Viktoria Bogner-Flatz

Medicine and Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

S100B is may complement the diagnostic tool set for mild TBI. Under certain circumstances the S100B measurement can replace a traditional CT imaging scan in suspected TBI. During longer hospitalization, S100B levels can provide insights regarding patient progression and outcome. Increased S100B concentration does not conclusively prove cerebral damage, but a physiological concentration in adult patients admitted with TBI does rule out cerebral damage with sufficient certainty. In an adult patient with a Glasgow Coma score of at least 14, presenting within 6 hours of head injury, guidelines suggest that an S100B level below 0.1 microgram/liter can prevent the need for a head CT scan.

Original language	English
Title of host publication	Biomarkers for Traumatic Brain Injury
Publisher	Elsevier
Pages	155-167
Number of pages	13
ISBN (Electronic)	9780128163467
DOIs	https://doi.org/10.1016/B978-0-12-816346-7.00010-5
State	Published - 1 Jan 2020

Keywords

Brain injury
S100B
TBI
biomarker
extracerebral source
half-life

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10.1016/B978-0-12-816346-7.00010-5

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KW - extracerebral source

KW - half-life

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S100 biomarkers in patients with traumatic brain injury

Abstract

Keywords

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