Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: Synthesis, DNA interactions and in vitro properties

Dennis J.M. Snelders; Angela Casini; Fabio Edafe; Gerard Van Koten; Robertus J.M. Klein Gebbink; Paul J. Dyson

doi:10.1016/j.jorganchem.2010.11.025

Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: Synthesis, DNA interactions and in vitro properties

Dennis J.M. Snelders, Angela Casini, Fabio Edafe, Gerard Van Koten, Robertus J.M. Klein Gebbink, Paul J. Dyson

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16 Scopus citations

Abstract

The synthesis, DNA binding properties and cytotoxicity of a series of Ru(II)-arene complexes containing oligocationic ammonium-functionalized triarylphosphines, of the type Ru(p-cymene)Cl₂(L) (L = oligocationic phosphine), are reported. The complexes are highly charged (the overall charge states being +3 and +6) and circular dichroism spectroscopy and gel electrophoresis studies indicate that the compounds interact strongly with DNA via electrostatic interactions. Despite forming strong interactions with DNA, the complexes exhibit only modest cytotoxicities on the human ovarian cancer cell lines A2780 and A2780cisR.

Original language	English
Pages (from-to)	1108-1116
Number of pages	9
Journal	Journal of Organometallic Chemistry
Volume	696
Issue number	5
DOIs	https://doi.org/10.1016/j.jorganchem.2010.11.025
State	Published - 1 Mar 2011
Externally published	Yes

Keywords

Bioorganometallic chemistry
DNA binding
Metal-based drugs
Phosphine ligands
Ruthenium

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jorganchem.2010.11.025

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title = "Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: Synthesis, DNA interactions and in vitro properties",

abstract = "The synthesis, DNA binding properties and cytotoxicity of a series of Ru(II)-arene complexes containing oligocationic ammonium-functionalized triarylphosphines, of the type Ru(p-cymene)Cl2(L) (L = oligocationic phosphine), are reported. The complexes are highly charged (the overall charge states being +3 and +6) and circular dichroism spectroscopy and gel electrophoresis studies indicate that the compounds interact strongly with DNA via electrostatic interactions. Despite forming strong interactions with DNA, the complexes exhibit only modest cytotoxicities on the human ovarian cancer cell lines A2780 and A2780cisR.",

keywords = "Bioorganometallic chemistry, DNA binding, Metal-based drugs, Phosphine ligands, Ruthenium",

author = "Snelders, {Dennis J.M.} and Angela Casini and Fabio Edafe and {Van Koten}, Gerard and {Klein Gebbink}, {Robertus J.M.} and Dyson, {Paul J.}",

note = "Funding Information: The authors thank Ecole Polytechnique F{\'e}d{\'e}rale de Lausanne (EPFL) for financial support. ",

year = "2011",

month = mar,

day = "1",

doi = "10.1016/j.jorganchem.2010.11.025",

language = "English",

volume = "696",

pages = "1108--1116",

journal = "Journal of Organometallic Chemistry",

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publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands

T2 - Synthesis, DNA interactions and in vitro properties

AU - Snelders, Dennis J.M.

AU - Casini, Angela

AU - Edafe, Fabio

AU - Van Koten, Gerard

AU - Klein Gebbink, Robertus J.M.

AU - Dyson, Paul J.

N1 - Funding Information: The authors thank Ecole Polytechnique Fédérale de Lausanne (EPFL) for financial support.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - The synthesis, DNA binding properties and cytotoxicity of a series of Ru(II)-arene complexes containing oligocationic ammonium-functionalized triarylphosphines, of the type Ru(p-cymene)Cl2(L) (L = oligocationic phosphine), are reported. The complexes are highly charged (the overall charge states being +3 and +6) and circular dichroism spectroscopy and gel electrophoresis studies indicate that the compounds interact strongly with DNA via electrostatic interactions. Despite forming strong interactions with DNA, the complexes exhibit only modest cytotoxicities on the human ovarian cancer cell lines A2780 and A2780cisR.

AB - The synthesis, DNA binding properties and cytotoxicity of a series of Ru(II)-arene complexes containing oligocationic ammonium-functionalized triarylphosphines, of the type Ru(p-cymene)Cl2(L) (L = oligocationic phosphine), are reported. The complexes are highly charged (the overall charge states being +3 and +6) and circular dichroism spectroscopy and gel electrophoresis studies indicate that the compounds interact strongly with DNA via electrostatic interactions. Despite forming strong interactions with DNA, the complexes exhibit only modest cytotoxicities on the human ovarian cancer cell lines A2780 and A2780cisR.

KW - Bioorganometallic chemistry

KW - DNA binding

KW - Metal-based drugs

KW - Phosphine ligands

KW - Ruthenium

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U2 - 10.1016/j.jorganchem.2010.11.025

DO - 10.1016/j.jorganchem.2010.11.025

M3 - Article

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SN - 0022-328X

VL - 696

SP - 1108

EP - 1116

JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

IS - 5

ER -

Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: Synthesis, DNA interactions and in vitro properties

Abstract

Keywords

UN SDGs

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