Ruthenium-catalyzed transfer hydrogenation of nitriles: Reduction and subsequent N-monoalkylation to secondary amines

Svenja Werkmeister, Christoph Bornschein, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The selective synthesis of amines continues to be of importance because of their application in the bulk and fine chemical industries. Herein, domino ruthenium-catalyzed transfer hydrogenation of nitriles with subsequent N-monoalkylation by using alcohols is described. With this novel approach, various nitriles were reductively N-monoalkylated in excellent yields. A simple method for the synthesis of secondary amines starting directly from nitriles by using a ruthenium catalyst is described. With this novel domino system, various nitriles were reduced and subsequently N-monoalkylated in excellent yields (up to 99 %). In addition to isopropanol, other alcohols were also used as a reductant and N-monoalkylation reagent.

Original languageEnglish
Pages (from-to)3671-3674
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number18
DOIs
StatePublished - Jun 2013
Externally publishedYes

Keywords

  • Alkylation
  • Amines
  • Nitriles
  • Ruthenium
  • Transfer hydrogenation

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