Ruthenium-catalyzed selective monoamination of vicinal diols

Sebastian Bähn, Annegret Tillack, Sebastian Imm, Kathleen Mevius, Dirk Michalik, Dirk Hollmann, Lorenz Neubert, Matthias Beller

Research output: Contribution to journalArticlepeer-review

87 Scopus citations


The monoamination of vicinal diols in the presence of in situ generated ruthenium catalysts has been investigated. Among the various phosphines tested in combination with [Ru3(CO)12], N-phenyl-2-(dicyclohexyl-phosphanyl)pyrrole showed the best performance. After optimization of the reaction conditions this system was applied to different secondary amines and anilines as well as a number of vicinal diols. With the exception of ethylene glycol, monoamination of the vicinal diols occurred selectively and the corresponding amino alcohols were obtained in good yields, producing water as the only side product.

Original languageEnglish
Pages (from-to)551-557
Number of pages7
Issue number6
StatePublished - Jun 2009
Externally publishedYes


  • Alcohols
  • Amination
  • Amino alcohols
  • P ligands
  • Ruthenium


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