Rolle des angeborenen Immunsystems bei Otitis media

Translated title of the contribution: The role of innate immunity in otitis media

M. Wigand, T. K. Hoffmann, A. F. Ryan, B. Wollenberg, A. Leichtle

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Otitis media (OM) belongs to the most common pediatric diseases and causes more medical contacts, surgical interventions, and drug prescriptions than any other infectious disease. Recent findings have identified a critical role of innate immunity in recovery from OM. The middle ear mucosa identifies invading pathogens by sensing pathogen-associated molecule patterns (PAMPs) via pattern recognition receptors such as the Toll-like receptors (TLRs). They generate immediate antimicrobial responses and cytokine release, leading to an inflammatory reaction as seen in acute or chronic OM. Cross-talk between TLRs can enhance or suppress the healing process in the middle ear. In order to prevent over-activation on the one hand and insufficient immune response on the other, the signaling network between different TLRs must be integrated and controlled by positive and negative feedback loops. This guarantees a proper immune response in the middle ear after infection. In this review, we focus on the involvement of the innate immune system and TLRs in OM, as well on their relevance for new vaccination strategies and immunotherapies.

Translated title of the contributionThe role of innate immunity in otitis media
Original languageGerman
Pages (from-to)464-471
Number of pages8
Issue number6
StatePublished - 1 Jun 2018
Externally publishedYes


Dive into the research topics of 'The role of innate immunity in otitis media'. Together they form a unique fingerprint.

Cite this