Role of sGC-dependent NO signalling and myocardial infarction risk

Jana Wobst; Thorsten Kessler; Tan An Dang; Jeanette Erdmann; Heribert Schunkert

doi:10.1007/s00109-015-1265-3

Role of sGC-dependent NO signalling and myocardial infarction risk

Jana Wobst, Thorsten Kessler, Tan An Dang, Jeanette Erdmann, Heribert Schunkert

Clinic for Heart and Vascular Diseases

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

The NO/cGMP pathway plays an important role in many physiological functions and pathophysiological conditions. In the last few years, several genetic and functional studies pointed to an underestimated role of this pathway in the development of atherosclerosis. Indeed, several genetic variants of key enzymes modulating the generation of NO and cGMP have been strongly associated with coronary artery disease and myocardial infarction risk. In this review, we aim to place the genomic findings on components of the NO/cGMP pathway, namely endothelial nitric oxide synthase, soluble guanylyl cyclase and phosphodiesterase 5A, in context of preventive and therapeutic strategies for treating atherosclerosis and its sequelae.

Original language	English
Pages (from-to)	383-394
Number of pages	12
Journal	Journal of Molecular Medicine
Volume	93
Issue number	4
DOIs	https://doi.org/10.1007/s00109-015-1265-3
State	Published - 20 Mar 2015

Keywords

Coronary artery disease (CAD)
Myocardial infarction (MI)
Nitrate-nitrite-NO pathway
Nitric oxide (NO)/cyclic guanosine-3′,5′-monophosphate (cGMP) pathway
Nitric oxide synthases (NOS)
Phosphodiesterase 5 (PDE5)
Soluble guanylyl cyclase (sGC)
l-arginine-NOS pathway

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10.1007/s00109-015-1265-3

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title = "Role of sGC-dependent NO signalling and myocardial infarction risk",

abstract = "The NO/cGMP pathway plays an important role in many physiological functions and pathophysiological conditions. In the last few years, several genetic and functional studies pointed to an underestimated role of this pathway in the development of atherosclerosis. Indeed, several genetic variants of key enzymes modulating the generation of NO and cGMP have been strongly associated with coronary artery disease and myocardial infarction risk. In this review, we aim to place the genomic findings on components of the NO/cGMP pathway, namely endothelial nitric oxide synthase, soluble guanylyl cyclase and phosphodiesterase 5A, in context of preventive and therapeutic strategies for treating atherosclerosis and its sequelae.",

keywords = "Coronary artery disease (CAD), Myocardial infarction (MI), Nitrate-nitrite-NO pathway, Nitric oxide (NO)/cyclic guanosine-3′,5′-monophosphate (cGMP) pathway, Nitric oxide synthases (NOS), Phosphodiesterase 5 (PDE5), Soluble guanylyl cyclase (sGC), l-arginine-NOS pathway",

author = "Jana Wobst and Thorsten Kessler and Dang, {Tan An} and Jeanette Erdmann and Heribert Schunkert",

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AU - Wobst, Jana

AU - Kessler, Thorsten

AU - Dang, Tan An

AU - Erdmann, Jeanette

AU - Schunkert, Heribert

PY - 2015/3/20

Y1 - 2015/3/20

N2 - The NO/cGMP pathway plays an important role in many physiological functions and pathophysiological conditions. In the last few years, several genetic and functional studies pointed to an underestimated role of this pathway in the development of atherosclerosis. Indeed, several genetic variants of key enzymes modulating the generation of NO and cGMP have been strongly associated with coronary artery disease and myocardial infarction risk. In this review, we aim to place the genomic findings on components of the NO/cGMP pathway, namely endothelial nitric oxide synthase, soluble guanylyl cyclase and phosphodiesterase 5A, in context of preventive and therapeutic strategies for treating atherosclerosis and its sequelae.

AB - The NO/cGMP pathway plays an important role in many physiological functions and pathophysiological conditions. In the last few years, several genetic and functional studies pointed to an underestimated role of this pathway in the development of atherosclerosis. Indeed, several genetic variants of key enzymes modulating the generation of NO and cGMP have been strongly associated with coronary artery disease and myocardial infarction risk. In this review, we aim to place the genomic findings on components of the NO/cGMP pathway, namely endothelial nitric oxide synthase, soluble guanylyl cyclase and phosphodiesterase 5A, in context of preventive and therapeutic strategies for treating atherosclerosis and its sequelae.

KW - Coronary artery disease (CAD)

KW - Myocardial infarction (MI)

KW - Nitrate-nitrite-NO pathway

KW - Nitric oxide (NO)/cyclic guanosine-3′,5′-monophosphate (cGMP) pathway

KW - Nitric oxide synthases (NOS)

KW - Phosphodiesterase 5 (PDE5)

KW - Soluble guanylyl cyclase (sGC)

KW - l-arginine-NOS pathway

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SP - 383

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JO - Journal of Molecular Medicine

JF - Journal of Molecular Medicine

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Role of sGC-dependent NO signalling and myocardial infarction risk

Abstract

Keywords

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