Role of heat shock proteins in immune modulation in malaria

Evelyn Böttger; Gabriele Multhoff

doi:10.1007/978-94-007-7438-4_7

Role of heat shock proteins in immune modulation in malaria

Evelyn Böttger
, Gabriele Multhoff

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Malaria still remains one of the most devastating infectious diseases world-wide causing ~∈655,000 deaths per year World Health Organization (WHO) report 2011. In humans, malaria can be caused through infection with five different species of the apicomplexan parasite Plasmodium. Immunity against Plasmodium falciparum (P. falciparum), the most dangerous malaria species, develops incompletely over the course of multiple infection cycles. Protective immunity against malaria should involve the humoral, innate, and adaptive system. However, the human immune system often fails to eliminate malaria infections completely for yet unknown reasons. In the present chapter we aim to elucidate the role of the host's and the parasite's heat shock proteins (HSPs) in the development of a novel anti-malaria therapeutic approach.

Original language	English
Title of host publication	Heat Shock Proteins of Malaria
Publisher	Springer Netherlands
Pages	119-132
Number of pages	14
ISBN (Electronic)	9789400774384
ISBN (Print)	9400774370, 9789400774377
DOIs	https://doi.org/10.1007/978-94-007-7438-4_7
State	Published - 1 Nov 2013
Externally published	Yes

Keywords

Eryptosis
Granzyme B
Host heat shock protein
NK cell immunotherapy
Parasite heat shock protein
Plasmodium infected erythrocytes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-94-007-7438-4_7

Cite this

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abstract = "Malaria still remains one of the most devastating infectious diseases world-wide causing \textasciitilde{}∈655,000 deaths per year World Health Organization (WHO) report 2011. In humans, malaria can be caused through infection with five different species of the apicomplexan parasite Plasmodium. Immunity against Plasmodium falciparum (P. falciparum), the most dangerous malaria species, develops incompletely over the course of multiple infection cycles. Protective immunity against malaria should involve the humoral, innate, and adaptive system. However, the human immune system often fails to eliminate malaria infections completely for yet unknown reasons. In the present chapter we aim to elucidate the role of the host's and the parasite's heat shock proteins (HSPs) in the development of a novel anti-malaria therapeutic approach.",

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T1 - Role of heat shock proteins in immune modulation in malaria

AU - Böttger, Evelyn

AU - Multhoff, Gabriele

N1 - Publisher Copyright: © Springer Science+Business Media Dordrecht 2014. All rights are reserved.

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Malaria still remains one of the most devastating infectious diseases world-wide causing ~∈655,000 deaths per year World Health Organization (WHO) report 2011. In humans, malaria can be caused through infection with five different species of the apicomplexan parasite Plasmodium. Immunity against Plasmodium falciparum (P. falciparum), the most dangerous malaria species, develops incompletely over the course of multiple infection cycles. Protective immunity against malaria should involve the humoral, innate, and adaptive system. However, the human immune system often fails to eliminate malaria infections completely for yet unknown reasons. In the present chapter we aim to elucidate the role of the host's and the parasite's heat shock proteins (HSPs) in the development of a novel anti-malaria therapeutic approach.

AB - Malaria still remains one of the most devastating infectious diseases world-wide causing ~∈655,000 deaths per year World Health Organization (WHO) report 2011. In humans, malaria can be caused through infection with five different species of the apicomplexan parasite Plasmodium. Immunity against Plasmodium falciparum (P. falciparum), the most dangerous malaria species, develops incompletely over the course of multiple infection cycles. Protective immunity against malaria should involve the humoral, innate, and adaptive system. However, the human immune system often fails to eliminate malaria infections completely for yet unknown reasons. In the present chapter we aim to elucidate the role of the host's and the parasite's heat shock proteins (HSPs) in the development of a novel anti-malaria therapeutic approach.

KW - Eryptosis

KW - Granzyme B

KW - Host heat shock protein

KW - NK cell immunotherapy

KW - Parasite heat shock protein

KW - Plasmodium infected erythrocytes

UR - https://www.scopus.com/pages/publications/84904268467

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DO - 10.1007/978-94-007-7438-4_7

M3 - Chapter

AN - SCOPUS:84904268467

SN - 9400774370

SN - 9789400774377

SP - 119

EP - 132

BT - Heat Shock Proteins of Malaria

PB - Springer Netherlands

ER -

Role of heat shock proteins in immune modulation in malaria

Abstract

Keywords

UN SDGs

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