Abstract
Animal obesity models differ widely in type and extent of obesity. They are either based on environmental factors (eg. high fat diet induced obesity), spontaneous mutants (i.e. ob/ob mice), genetically engineered animals (eg. mice with melanocortin receptor subtype-4 gene disruption (knock-out)) or mechanical intervention (eg. chemical lesion of the ventromedial hypothalamus). This article reviews available rodent models to study obesity and attempts to highlight the greatest utility for each model.
| Original language | English |
|---|---|
| Pages (from-to) | 307-319 |
| Number of pages | 13 |
| Journal | Experimental and Clinical Endocrinology and Diabetes |
| Volume | 109 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
Keywords
- Animal model
- Bariatric research
- Energy balance
- Obesity
