Robust sample preparation on digital microfluidic biochips

Zhanwei Zhong; Robert Wille; Krishnendu Chakrabarty

doi:10.1145/3287624.3287709

Robust sample preparation on digital microfluidic biochips

Zhanwei Zhong, Robert Wille, Krishnendu Chakrabarty

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

6 Scopus citations

Abstract

Sample preparation is an important application for the digital microfluidic biochips (DMFBs) platform, and many methods have been developed to reduce the time and reagent usage associated with on-chip sample preparation. However, errors in fluidic operations can result in the concentration of the resulting droplet being outside the calibration range. Current error-recovery methods have the drawback that they need the use of on-chip sensors and further re-execution time. In this paper, we present two dilution-chain structures that can generate a droplet with a desired concentration even if volume variations occur during droplet splitting. Experimental results show the effectiveness of the proposed method compared to previous methods.

Original language	English
Title of host publication	ASP-DAC 2019 - 24th Asia and South Pacific Design Automation Conference
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	512-517
Number of pages	6
ISBN (Electronic)	9781450360074
DOIs	https://doi.org/10.1145/3287624.3287709
State	Published - 21 Jan 2019
Externally published	Yes
Event	24th Asia and South Pacific Design Automation Conference, ASPDAC 2019 - Tokyo, Japan Duration: 21 Jan 2019 → 24 Jan 2019

Publication series

Name	Proceedings of the Asia and South Pacific Design Automation Conference, ASP-DAC

Conference

Conference	24th Asia and South Pacific Design Automation Conference, ASPDAC 2019
Country/Territory	Japan
City	Tokyo
Period	21/01/19 → 24/01/19

Keywords

Digital microfluidics
Robust
Sample preparation

Access to Document

10.1145/3287624.3287709

Cite this

Zhong, Z., Wille, R., & Chakrabarty, K. (2019). Robust sample preparation on digital microfluidic biochips. In ASP-DAC 2019 - 24th Asia and South Pacific Design Automation Conference (pp. 512-517). (Proceedings of the Asia and South Pacific Design Automation Conference, ASP-DAC). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1145/3287624.3287709

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title = "Robust sample preparation on digital microfluidic biochips",

abstract = "Sample preparation is an important application for the digital microfluidic biochips (DMFBs) platform, and many methods have been developed to reduce the time and reagent usage associated with on-chip sample preparation. However, errors in fluidic operations can result in the concentration of the resulting droplet being outside the calibration range. Current error-recovery methods have the drawback that they need the use of on-chip sensors and further re-execution time. In this paper, we present two dilution-chain structures that can generate a droplet with a desired concentration even if volume variations occur during droplet splitting. Experimental results show the effectiveness of the proposed method compared to previous methods.",

keywords = "Digital microfluidics, Robust, Sample preparation",

author = "Zhanwei Zhong and Robert Wille and Krishnendu Chakrabarty",

note = "Publisher Copyright: {\textcopyright} 2019 Association for Computing Machinery.; 24th Asia and South Pacific Design Automation Conference, ASPDAC 2019 ; Conference date: 21-01-2019 Through 24-01-2019",

year = "2019",

month = jan,

day = "21",

doi = "10.1145/3287624.3287709",

language = "English",

series = "Proceedings of the Asia and South Pacific Design Automation Conference, ASP-DAC",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

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booktitle = "ASP-DAC 2019 - 24th Asia and South Pacific Design Automation Conference",

}

Zhong, Z, Wille, R & Chakrabarty, K 2019, Robust sample preparation on digital microfluidic biochips. in ASP-DAC 2019 - 24th Asia and South Pacific Design Automation Conference. Proceedings of the Asia and South Pacific Design Automation Conference, ASP-DAC, Institute of Electrical and Electronics Engineers Inc., pp. 512-517, 24th Asia and South Pacific Design Automation Conference, ASPDAC 2019, Tokyo, Japan, 21/01/19. https://doi.org/10.1145/3287624.3287709

Robust sample preparation on digital microfluidic biochips. / Zhong, Zhanwei; Wille, Robert; Chakrabarty, Krishnendu.
ASP-DAC 2019 - 24th Asia and South Pacific Design Automation Conference. Institute of Electrical and Electronics Engineers Inc., 2019. p. 512-517 (Proceedings of the Asia and South Pacific Design Automation Conference, ASP-DAC).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Robust sample preparation on digital microfluidic biochips

AU - Zhong, Zhanwei

AU - Wille, Robert

AU - Chakrabarty, Krishnendu

PY - 2019/1/21

Y1 - 2019/1/21

N2 - Sample preparation is an important application for the digital microfluidic biochips (DMFBs) platform, and many methods have been developed to reduce the time and reagent usage associated with on-chip sample preparation. However, errors in fluidic operations can result in the concentration of the resulting droplet being outside the calibration range. Current error-recovery methods have the drawback that they need the use of on-chip sensors and further re-execution time. In this paper, we present two dilution-chain structures that can generate a droplet with a desired concentration even if volume variations occur during droplet splitting. Experimental results show the effectiveness of the proposed method compared to previous methods.

AB - Sample preparation is an important application for the digital microfluidic biochips (DMFBs) platform, and many methods have been developed to reduce the time and reagent usage associated with on-chip sample preparation. However, errors in fluidic operations can result in the concentration of the resulting droplet being outside the calibration range. Current error-recovery methods have the drawback that they need the use of on-chip sensors and further re-execution time. In this paper, we present two dilution-chain structures that can generate a droplet with a desired concentration even if volume variations occur during droplet splitting. Experimental results show the effectiveness of the proposed method compared to previous methods.

KW - Digital microfluidics

KW - Robust

KW - Sample preparation

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U2 - 10.1145/3287624.3287709

DO - 10.1145/3287624.3287709

M3 - Conference contribution

AN - SCOPUS:85061147518

T3 - Proceedings of the Asia and South Pacific Design Automation Conference, ASP-DAC

SP - 512

EP - 517

BT - ASP-DAC 2019 - 24th Asia and South Pacific Design Automation Conference

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 24th Asia and South Pacific Design Automation Conference, ASPDAC 2019

Y2 - 21 January 2019 through 24 January 2019

ER -

Robust sample preparation on digital microfluidic biochips

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