Roadmap on nanomedicine for the central nervous system

Gianni Ciofani; Marco Campisi; Clara Mattu; Roger D. Kamm; Valeria Chiono; Aji Alex Moothedathu Raynold; João S. Freitas; Eugenio Redolfi Riva; Silvestro Micera; Carlotta Pucci; Fernando Novio; Julia Lorenzo; Daniel Ruiz-Molina; Giulia Sierri; Francesca Re; Hannah Wunderlich; Prachi Kumari; Kristen L. Kozielski; Mounia Chami; Attilio Marino; Lino Ferreira

doi:10.1088/2515-7639/acab88

Roadmap on nanomedicine for the central nervous system

Gianni Ciofani, Marco Campisi, Clara Mattu, Roger D. Kamm, Valeria Chiono, Aji Alex Moothedathu Raynold, João S. Freitas, Eugenio Redolfi Riva, Silvestro Micera, Carlotta Pucci, Fernando Novio, Julia Lorenzo, Daniel Ruiz-Molina, Giulia Sierri, Francesca Re, Hannah Wunderlich, Prachi Kumari, Kristen L. Kozielski, Mounia Chami, Attilio MarinoLino Ferreira

Assistant Professorship of Neuroengineering Materials

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

In recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier acts as an obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the CNS one of the most significant challenges in medicine. In this Roadmap article, we present the status of the timeliest developments in the field, and identify the outstanding challenges and opportunities that exist. The format of the Roadmap, whereby experts in each discipline share their viewpoint and present their vision, reflects the dynamic and multidisciplinary nature of this research area, and is intended to generate dialogue and collaboration across traditional subject areas. It is stressed here that this article is not intended to act as a comprehensive review article, but rather an up-to-date and forward-looking summary of research methodologies pertaining to the treatment of pathologies at the level of the CNS.

Original language	English
Article number	022501
Journal	JPhys Materials
Volume	6
Issue number	2
DOIs	https://doi.org/10.1088/2515-7639/acab88
State	Published - 1 Apr 2023

Keywords

blood-brain barrier
central nervous system
drug delivery
introductions
nanomedicines
roadmap

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10.1088/2515-7639/acab88

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Ciofani, G., Campisi, M., Mattu, C., Kamm, R. D., Chiono, V., Raynold, A. A. M., Freitas, J. S., Redolfi Riva, E., Micera, S., Pucci, C., Novio, F., Lorenzo, J., Ruiz-Molina, D., Sierri, G., Re, F., Wunderlich, H., Kumari, P., Kozielski, K. L., Chami, M., ... Ferreira, L. (2023). Roadmap on nanomedicine for the central nervous system. JPhys Materials, 6(2), Article 022501. https://doi.org/10.1088/2515-7639/acab88

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abstract = "In recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier acts as an obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the CNS one of the most significant challenges in medicine. In this Roadmap article, we present the status of the timeliest developments in the field, and identify the outstanding challenges and opportunities that exist. The format of the Roadmap, whereby experts in each discipline share their viewpoint and present their vision, reflects the dynamic and multidisciplinary nature of this research area, and is intended to generate dialogue and collaboration across traditional subject areas. It is stressed here that this article is not intended to act as a comprehensive review article, but rather an up-to-date and forward-looking summary of research methodologies pertaining to the treatment of pathologies at the level of the CNS.",

keywords = "blood-brain barrier, central nervous system, drug delivery, introductions, nanomedicines, roadmap",

author = "Gianni Ciofani and Marco Campisi and Clara Mattu and Kamm, {Roger D.} and Valeria Chiono and Raynold, {Aji Alex Moothedathu} and Freitas, {Jo{\~a}o S.} and {Redolfi Riva}, Eugenio and Silvestro Micera and Carlotta Pucci and Fernando Novio and Julia Lorenzo and Daniel Ruiz-Molina and Giulia Sierri and Francesca Re and Hannah Wunderlich and Prachi Kumari and Kozielski, {Kristen L.} and Mounia Chami and Attilio Marino and Lino Ferreira",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by IOP Publishing Ltd.",

year = "2023",

month = apr,

day = "1",

doi = "10.1088/2515-7639/acab88",

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Ciofani, G, Campisi, M, Mattu, C, Kamm, RD, Chiono, V, Raynold, AAM, Freitas, JS, Redolfi Riva, E, Micera, S, Pucci, C, Novio, F, Lorenzo, J, Ruiz-Molina, D, Sierri, G, Re, F, Wunderlich, H, Kumari, P, Kozielski, KL, Chami, M, Marino, A & Ferreira, L 2023, 'Roadmap on nanomedicine for the central nervous system', JPhys Materials, vol. 6, no. 2, 022501. https://doi.org/10.1088/2515-7639/acab88

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T1 - Roadmap on nanomedicine for the central nervous system

AU - Ciofani, Gianni

AU - Campisi, Marco

AU - Mattu, Clara

AU - Kamm, Roger D.

AU - Chiono, Valeria

AU - Raynold, Aji Alex Moothedathu

AU - Freitas, João S.

AU - Redolfi Riva, Eugenio

AU - Micera, Silvestro

AU - Pucci, Carlotta

AU - Novio, Fernando

AU - Lorenzo, Julia

AU - Ruiz-Molina, Daniel

AU - Sierri, Giulia

AU - Re, Francesca

AU - Wunderlich, Hannah

AU - Kumari, Prachi

AU - Kozielski, Kristen L.

AU - Chami, Mounia

AU - Marino, Attilio

AU - Ferreira, Lino

PY - 2023/4/1

Y1 - 2023/4/1

N2 - In recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier acts as an obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the CNS one of the most significant challenges in medicine. In this Roadmap article, we present the status of the timeliest developments in the field, and identify the outstanding challenges and opportunities that exist. The format of the Roadmap, whereby experts in each discipline share their viewpoint and present their vision, reflects the dynamic and multidisciplinary nature of this research area, and is intended to generate dialogue and collaboration across traditional subject areas. It is stressed here that this article is not intended to act as a comprehensive review article, but rather an up-to-date and forward-looking summary of research methodologies pertaining to the treatment of pathologies at the level of the CNS.

AB - In recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier acts as an obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the CNS one of the most significant challenges in medicine. In this Roadmap article, we present the status of the timeliest developments in the field, and identify the outstanding challenges and opportunities that exist. The format of the Roadmap, whereby experts in each discipline share their viewpoint and present their vision, reflects the dynamic and multidisciplinary nature of this research area, and is intended to generate dialogue and collaboration across traditional subject areas. It is stressed here that this article is not intended to act as a comprehensive review article, but rather an up-to-date and forward-looking summary of research methodologies pertaining to the treatment of pathologies at the level of the CNS.

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VL - 6

JO - JPhys Materials

JF - JPhys Materials

IS - 2

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ER -

Roadmap on nanomedicine for the central nervous system

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Keywords

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