RNA interference-based strategies for metabolic syndrome treatment

Andreas Barthel; S. Herzig; H. W. Müller; J. Harborth; S. R. Bornstein

doi:10.1055/s-2005-861157

RNA interference-based strategies for metabolic syndrome treatment

Andreas Barthel
, S. Herzig
, H. W. Müller
, J. Harborth
, S. R. Bornstein

Medical Faculty and University Hospital Düsseldorf
German Cancer Research Center
Alnylam Pharmaceuticals, Inc.
Technische Universität Dresden

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

RNA interference is a naturally occurring cellular mechanism to inhibit the expression of specific gene products. The technical application of RNA interference offers great potential for the specific treatment of a huge variety of diseases including the metabolic syndrome, one of the most challenging threats to human health associated with our civilization. In order to develop novel and powerful strategies for the treatment of the metabolic syndrome, it is essential to define a set of specific gene products that may be targeted by RNA interference. Based on currently available in vitro and in vivo data, we discuss the feasibility of candidate genes involved in the pathophysiology of the metabolic syndrome as potential targets for a rational RNA interference based therapy in this review.

Original language	English
Pages (from-to)	59-62
Number of pages	4
Journal	Hormone and Metabolic Research
Volume	37
Issue number	2
DOIs	https://doi.org/10.1055/s-2005-861157
State	Published - Feb 2005
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adipose tissue
Hepatic glucose production
Insulin signaling
Metabolic syndrome
Renin-angiotensin-aldosterone system

Access to Document

10.1055/s-2005-861157

Cite this

@article{d9984341044e4485b4500d4c3ef07cf8,

title = "RNA interference-based strategies for metabolic syndrome treatment",

abstract = "RNA interference is a naturally occurring cellular mechanism to inhibit the expression of specific gene products. The technical application of RNA interference offers great potential for the specific treatment of a huge variety of diseases including the metabolic syndrome, one of the most challenging threats to human health associated with our civilization. In order to develop novel and powerful strategies for the treatment of the metabolic syndrome, it is essential to define a set of specific gene products that may be targeted by RNA interference. Based on currently available in vitro and in vivo data, we discuss the feasibility of candidate genes involved in the pathophysiology of the metabolic syndrome as potential targets for a rational RNA interference based therapy in this review.",

keywords = "Adipose tissue, Hepatic glucose production, Insulin signaling, Metabolic syndrome, Renin-angiotensin-aldosterone system",

author = "Andreas Barthel and S. Herzig and M{\"u}ller, \{H. W.\} and J. Harborth and Bornstein, \{S. R.\}",

year = "2005",

month = feb,

doi = "10.1055/s-2005-861157",

language = "English",

volume = "37",

pages = "59--62",

journal = "Hormone and Metabolic Research",

issn = "0018-5043",

publisher = "Georg Thieme Verlag",

number = "2",

}

TY - JOUR

T1 - RNA interference-based strategies for metabolic syndrome treatment

AU - Barthel, Andreas

AU - Herzig, S.

AU - Müller, H. W.

AU - Harborth, J.

AU - Bornstein, S. R.

PY - 2005/2

Y1 - 2005/2

N2 - RNA interference is a naturally occurring cellular mechanism to inhibit the expression of specific gene products. The technical application of RNA interference offers great potential for the specific treatment of a huge variety of diseases including the metabolic syndrome, one of the most challenging threats to human health associated with our civilization. In order to develop novel and powerful strategies for the treatment of the metabolic syndrome, it is essential to define a set of specific gene products that may be targeted by RNA interference. Based on currently available in vitro and in vivo data, we discuss the feasibility of candidate genes involved in the pathophysiology of the metabolic syndrome as potential targets for a rational RNA interference based therapy in this review.

AB - RNA interference is a naturally occurring cellular mechanism to inhibit the expression of specific gene products. The technical application of RNA interference offers great potential for the specific treatment of a huge variety of diseases including the metabolic syndrome, one of the most challenging threats to human health associated with our civilization. In order to develop novel and powerful strategies for the treatment of the metabolic syndrome, it is essential to define a set of specific gene products that may be targeted by RNA interference. Based on currently available in vitro and in vivo data, we discuss the feasibility of candidate genes involved in the pathophysiology of the metabolic syndrome as potential targets for a rational RNA interference based therapy in this review.

KW - Adipose tissue

KW - Hepatic glucose production

KW - Insulin signaling

KW - Metabolic syndrome

KW - Renin-angiotensin-aldosterone system

UR - https://www.scopus.com/pages/publications/15944418977

U2 - 10.1055/s-2005-861157

DO - 10.1055/s-2005-861157

M3 - Review article

C2 - 15778919

AN - SCOPUS:15944418977

SN - 0018-5043

VL - 37

SP - 59

EP - 62

JO - Hormone and Metabolic Research

JF - Hormone and Metabolic Research

IS - 2

ER -

RNA interference-based strategies for metabolic syndrome treatment

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this